David Sinclair on NMN Minimal Dose and BEST Timing

it comes to nmn which we've studied for a lot um and there are studies on nr in humans and i have some insights into animating humans as well though that work isn't yet published um i what can i reveal i can reveal that the taking doses uh say less than 250 milligrams don't have a big effect on nad in the blood that would make sense you do have to take high doses but it's complicated by the observation that a single dose won't have a big long lasting effect anyway excuse me we see that in mice

as well you take one hit of uh nmn and it'll go up maybe go about 50 and it'll quickly die away in levels but what's interesting in the mouse and the human studies is it's more like a positive stock market where over a period of in the case of the in our study that i'm thinking of after nine days it was an accumulation up to a certain level and so if a study has only done a one time point in a human or in a mouse uh be careful because that's probably misleading um and that

you know you want to measure these things after at least nine days and hopefully after a few months where and you know maybe show that those low doses actually start to kick in so what do i do i take a bolus in the morning i take a gram in the morning i know a gram is likely to be raising my antivirals during day i also try to time it with my natural circadian rhythm so nad will go up during the morning getting ready but if i take it at night uh what i find is that

i'm actually starting to interfere with my sleep patterns interesting yeah and a lot of people have told me that that's the case as well with resveratrol as well it actually makes sense there's a few science papers on this about um cert one which is the target one of the nad requiring enzymes that we study so cert one is also its activity cycling through the day with nad uh turning on genes are required for morning activities and going to sleep at night clearing the brain at night we think if you get those out of kilter uh

i mean it makes sense that you will not only affect your body's metabolism find it hard to sleep but you could even start to have the effects of jet lag inadvertently i'd like to think that by taking the nad boosters when i'm traveling i'm actually resetting my body's clock and i do find you know for me uh in my experience i do feel better if i reset my clock with an nad booster when i arrive at a in a new time zone in mice we do know that it's cycling uh through the day you know

let's see we're right on the cutting edge here you know you have a choice you can take it at at night or in the morning and i think that uh probably what's happening is if i take it just before i go to bed my body's not in a fasting state yet it's still got you know my dinner is still in there uh and so it's uh it's mimicking fasting it's raising energy levels just when it should should be starting to to tailor off i think probably what's happening joe's now that i'm thinking out loud is

towards the early morning your nad levels are going to start coming up because that's when your stomach's empty and you absorb a lot of nutrients overnight and as it's coming up towards you know waking up and in the early morning that's when i provide my boost [Music] so