Coagulation Cascade Animation - Physiology of Hemostasis

[Music] at the site of vessel injury the first platelets arrived to start sealing the wound simultaneously that coagulation cascade with its various coagulation factors is activated this involves two pathways the extrinsic and the intrinsic pathway extrinsic activation begins with now exposed molecules of the vessel wall such as tissue factor which forms a complex with factor 7 finally leading to the activation of factor 10 this factored 10a is the point at which the extrinsic and the intrinsic pathways of the coagulation cascade meet the intrinsic pathway consists of various coagulation factors activating each other in a chain

reaction at it set a complex with an additional cofactor is formed this complex now activate factor 10 since the two pathways merge at the level of factor 10a this factor has a pivotal role in the coagulation cascade further down the Cascade factor 10a in combination with 5a activate thrombin and induces the so-called thrombin birth one molecule of factor 10a can catalyze the formation of a thousand molecules of thrombin these large amounts of thrombin caused the further activation of platelets and the enhanced formation of fibrin fibrin then formed strands making up the mesh that stabilizes the

platelet plug in an arterial clot and holds together the red blood cells in a venous clot it can be concluded that the central role of factor 10a in the coagulation cascade makes it a viable target for therapeutic intervention in pathologically altered blood coagulation you