I ate one egg per hour every hour for a whole month well first things first to clarify I did in fact sleep that was an average so I ate 24 eggs per day two cartons for 30 days for a total of 720 eggs over one month now second thing second why did I do this setting aside from the fact that I'm a little bit crazy but crazy with a purpose generally well 10% I did this because I just like eggs 20% I did this for the egg puns and yolks I'll drop throughout the video can
you C L7 but the main reason well you'll have to wait a little bit longer to find out anyway I hypothesized that eating 720 eggs in one month which alone amounts to 133,00 mg of cholesterol would not increase my cholesterol specifically it would not increase my LDL cholesterol and indeed drum roll it didn't not a smidge all those eggs did not increase my cholesterol even though my dietary intake of cholesterol more than twin tled my LDL cholesterol actually dropped by 2% over the first 2 weeks and then it dropped by 18 more per over the
subsequent 2 weeks I'll explain this change in drop slope in a moment but first there's mechanistic reason for why dietary cholesterol doesn't increase cholesterol serum cholesterol all things being equal as I've explained in other videos you can check out this video while it's been known for some time that dietary cholesterol has very little impact on normal people's cholesterol levels it was only recently discovered as to why this is the mechanism briefly just highle summary when you eat cholesterol the cholesterol binds to receptors on gut cells and this stimulates the release of a hormone called chisin
and chisin binds to its receptor on the liver called gpr1 146 and this inhibits endogenous cholesterol synthesis by the liver so things balance out and the homeostasis is maintained for more on those data again check out this video it's exciting science exciting science and it will definitely scramble your brain now why did my LDL not change over the first 2 weeks and then drop about 18% over the final two weeks what accounts for that change in drop slope well carbohydrates dietary carbohydrates if you follow me you almost certainly know about the famous Oreo versus Statin
experiment where I demonstrated consistent with our prior literature including case series and Interventional trials a meta analysis of randomized control trials and our understanding of lipid physiology in lean people who go low carb that adding back carbs really of any sort be it Oreos fruit or starches is sufficient to reduce LDL in the so-called lean mass Hypes phenotype check out more on that below but briefly in lean insulin sensitive people who go on low carbohydrate diets especially ketogenic diets it's common for LDL levels to rise as part of a lipid Triad including high LDL High
HDL in low triglycerides and this lipid Triad we think constitutes a metabolic signature of an extreme shift from carb burning to fat burning whereby vldl particles exported from the liver are turned over at fat and muscle tissue leading to a jump in LDL a jump in HDL and low triglycerides again check out the content below for more on that but adding back carbs reduces the need for an upregulation in systemic lipid trafficking through the cholesterol system and this phenotype the high LDL High h L low triglyceride phenotype reverts and LDL drops otherwise and very simply
stated adding back carbs can drop LDL at least in these lean mass hyperresponders and yes any net carbs will work in this case I chose primarily fruit and a modest dose just 60 G of net carbs for the final two weeks and included bananas blueberries strawberries and a few Frozen cherries that I honestly dip in Macadamia butter because I love Macadamia butter anyway I chose this dose the 60 dose out of curiosity because I knew 60 G per day wouldn't be enough to totally reverse my lean mass Hypes phenotype and drop my LDL cholesterol to
quote normal levels which is about 90 Mig per deer for me when I'm on a mixed standard American style Diet before I went keto but I figured 60 G would be enough to have some effect I probably EB and flow out of ketosis and the effect was sizable an 18% drop now if I doubled that dose to 120 g per day I think I would have seen closer to the 71% drop I saw with the Oreo cookies but more to the point here is that in the battle between conventional wisdom and platitudes and outside the
box thinking based on new understanding of physiology I.E super high cholesterol intake through a ton of eggs versus just a little bit of fruit the extra dose of carbs dominated over the insane amounts of cholesterol I was eating again over the month at least 133,00 milligrams and dietary fat as well to tally up the math in the final two weeks where I was also eating a little bit of fruit I was eating at least 75 grams per day of saturated fat and about 5,000 milligram per day of dietary cholesterol which is a lot more than
my usual and despite this the quote blueberry power I guess berries and bananas dominated on my cholesterol and dropped it by 18% now I realized this video isn't fully self-contained in so far as I haven't delved too deep into the lipid energy model and the physiology that predicts this response again again you can check out more content linked below but there's a reason for that which gets me back to the why for why I did this video in the first place what you'll find no surprise is that more extreme messages carry further they become means
they can self-propagate and spread a message sadly the messages on social media particularly in the diet space are often shallow or Hollow but in their best forms I think they can serve as intellectual provocation to bring people together provided those people are willing to listen to to the words being said and the actual arguments being made when you go a level deeper beyond the packaging beyond the carton beyond the shell I've found utility in this form of legit bait approach starting with the Oreo versus Statin study which was kind of a social experiment for me
and as silly as it may seem it did capture the attention not only of a large volume of people but it also captured the attention of important parties including other researchers and clinicians who are now on board and aware of the work we are doing and they investing Ed in it they're helping us push it forward so in the end this video isn't about eggs at all it's actually a reflection exercise for both me and you for me I'm interested to see what responses this video receives versus my standard basic science breakdown Fair presumably if
this video gets more clicks it's because of the packaging the eggs the shelf for you evidently you clicked on this video because you're watching it right now otherwise you wouldn't be hearing me speak and be honest with yourself I want you to reflect on why you clicked on this video was it because you thought there was a lesson to be learned that it would be entertaining or did you think it would be a devilish blend between the two was the click almost reflexive and if so what does that say about the population psychology of social
media influencing specifically within the nutrition and diet space if this is the video you chose to click perhaps that's a data point in a demonstration that the incentive structure drives content creators to give you extremes like 720 eggs now contemplate what's the effect of that what's the effect on me on you and then back on me is it bad or is it just a practical reality with which we need to contend I want you to leave your thoughts below let's continue this conversation authentically and for now that's all yolks