Anti-aging MD | How to reverse wrinkles, hair loss, and detox the body - supplements and treatment

then apart from collagen we have aanene and betacarotene they act as an internal sunscreen producing more melanin it may make sense to supplement luttin and better carotene but that convert into Vitamin A which accumulates and can become toxin whereas aanin does not orally hyaluronic acid has proven beneficial for both hydration and the aspect of wrinkles in several metanalysis so in the case of the skin I would say it's one of the easiest organs to regenerate we have to cause some harm to activate its regenerative capacity so what do we use usually we use when I

started almost 10 years ago my wrinkles in the eyelid area were deeper I haven't evolved any deep expression wrinkles although I tend to use my forehead a lot when I read and I haven't used Botox on myself Alex welcome to the podcast thank you for inviting me hi everyone today I'm with Alexis Ortega who is the medical doctor from Barcelona Spain he is the founder and medical director of adastra Clinic specialized to regenerative medicine longevity and skin he has worked as a medical adviser for longevity supplement startups as well as the Pharma industry and the

aesthetic medical industry collaborating in product development he has a board certification in regenerative medicine and master decrees in hair and skin aesthetic medicine and stem cell therapy and postgraduate diploma in longevity and anti-aging medicine whoow uh we also met met in India my mother couldn't have done it better we uh met in India a few months ago and that was very inspiring we were at the longevity Retreat that we were organizing and we did all sorts of longevity tests and treatments and had a very good chats and you also did a podcast with SE which

is super inspiring I would recommend everyone to also listen that one and we can kind of expand and go in depth in some of the areas of from from the discussion as well that you didn't cover necessarily uh that in depth um so let's start with just how did you get like you have such a massive background in longevity and regenerative medicine and you did like what 150 master's degrees and postgraduates so um I like to keep myself busy yeah I can see that so how did you get into the field of longevity like uh

there is probably hundreds of things that you can do as a doctor and specializations so what was it in longevity and aesthetic medicine that kind of called you yes definitely well I didn't start H my professional career in levity medicine I think it was part of our personal Evolution um as I started with the aesthetic Medical field so I started treating just doing boto fillers and and treating the external science of Aging so to speak um I started realizing of the importance of Aging itself and also the will of uh wanting to do something more

meaningful it's not that that Aesthetics uh cannot help people a lot with self-confidence and also by improving appear parents uh they have a different attitude towards life and they feel more active more youthful that's something I I've seen for a long time uh is that I wanted to complement or change the the focus of what I was doing I wanted to focus on the concept of regenitive medicine and apply it to Aesthetics and to pathologist so to help uh people in any way possible in any way that science can provide um in reducing their chances

of developing um any type of degenerative disease or chronic disease or if they have already developed it in improving uh their quality of life making helping them live healthier free of any burden for longer and also giving them a more youthful appearance but by treating the root cause of uh of their skin hair or appearance aging so that was the the main focus so you asked when I started uh doing that that that's uh as it's been a gradual process I would set the date in 2021 probably after the pandemic uh that's when when the

big shift took place uh I decided to to leave the clinic where I had worked for the past six years and I decided to open a new chapter uh and develop my own thing and that was uh that was the that was the turning point so I opened uh first a clinic in Palma de mayorca and then last year I opened one in Barcelona and there I am developing this concept of regen of medicine applied to longevity and Aesthetics and my main inspiration as I told Sim during our podcast was H auy de gray and

his theory of uh damage repair and strategies for negligible s Essence which focuses on identifying the different types of damage that appear with aging and apply a divide and conquer approach to tackle them with the goal of extending health and ultimately extending life that's great uh you do have quite a unique approach and quite a clear approach to longevity that I think makes a tons of sense can you walk us through briefly the three step process that you you developed M definitely so the main structure of my protocol has three phases and phase one would

be first and foremost diagnosis assessment so I do lots of tests that depends on on the profile on the patient profile but what I usually do is a very extensive comprehensive blood test a urine test and then more specialized tests such as telam epigenetic clocks n levels intracellular n levels not Blood N levels which are the ones that matter intracellular NAD levels also assessment of immune function not just by routine blood tests which only quantify the number of uh immune cells and subtypes that you have but the activity of those immune cells which is what

really matters what else um toxic heavy metals um we analyze them in the hair because it's the the most reliable source of uh metals and other toxins that accumulate in the body as opposed to blood and uh in in the most extensive protocol I also sequence the entire Genome of the patient to get to know all of his or her uh genetic risks so that would be step one assessment gather all the information and then with that we design a personalized PR precise protocol for face phase two which would be detox and phase three which

would be regeneration um I I kind of want to delve deeper into the detox today because I think that's extremely important and nobody really talks about it but before that one question that came into my mind is that is there have you noticed that there is like a one specific test that would be maybe more indicative of the of the regenerative capacity of that person than s you mentioned several tests NAD talir what not do you think there is something that's above all that it's like the most important for the most important one in clinical

medicine would be blood test and nothing surpasses that yet because it's a functional test it gives you it translates the way your organs are functioning today and with that you can predict mortality and health so the other tests are all complements but that doesn't mean that just by analyzing what's in your blood now we have enough information enough information to to achieve a good uh prevention in the future there's lots of things that we are ignoring so that's why I combine it with with those tests that provide some meaning F data that complement what we

know about your blood tests and I've had cases of patients with perfect blood tests no alterations and for for instance extremely low NAD levels and that in their case uh in in one specific case of uh that was diagnosed of chronic fatigue that was the root cause of his fatigue so it wasn't a nervous um um so fatigue I'm sure you're familiar with it it's uh sort of uh it's related with with the central nervous system and it implies alterations in neurotransmitters so in that case it was a misdiagnosis uh because just by improving n

levels which were abnormally low even for his age um we achieved remission of all his symptoms and he could get back to having a normal life chronic fatigue is sometimes used as a diagnosis when when no other explanation can be given yeah by the by the mainstream uh tests that is to and it's it's quite a difficult to treat or I I feel like a lot in a lot of the cases the patients are left without any tools they just say that that this is the this is the case now you have the chronic fatigue

and there is nothing that have been established could help sometimes it's uh the consequence of a chronic infection which is to me the most difficult cases to treat because there's already been a strong insult in the nervous system for example epin virus or cegala virus herpes virus and I've had patients that have had the three of them even followed by Corona virus so those are the tricky ones uh I think in those cases we must focus on uh improving all the antioxidant indices uh reducing chronic inflammation and stimulating uh tissue regeneration yeah but even with

that it's difficult yeah for sure okay then the second step of your approach is the detox and this is quite interesting so what are the most important things to detox from the F why why is detox in the first place for them F first of all let's explain to our audience that uh our bodies are constantly exposed to all sorts of toxins of junk either from the from the air we breathe from pollutants or from the water we drink or even from the clothes we wear from the microplastics so we have three main Windows of

entrance for the toxins one's the skin the other one's the air or lungs and the other one's the gut the intestine so [Music] um this has become a problem because we live far longer than what uh Evolution uh expects from us and we are surrounded by modernity we don't live in our natural environment so we've developed lots of technologies that have the downside of polluting the environment and polluting our bodies and therefore what we can do now is try to potentiate the body's ability to remove the innate ability The evolutionary ways the body has to

remove the types of junk it is familiar with so the ones it can remove and ate it in those that it is not familiar with and it cannot remove or it has more difficulty removing such as microplastics because we we haven't evolved surrounded by microplastics so we haven't evolved uh very efficient mechanism for removing them from the body right okay so what would be some of the tests to do to know if we are if we do have this uh old junk or we do have these external things in our bodies that we don't want

to keep there definitely in in this case as I told before I rely on hair mineral analysis it's basically having a few hairs removed a few hairs cut and analyzed and the content of the hair will tell you what has been accumulating in your body for the past two to three years so it's not like you have been exposed to Mercury because you you ate fish two days ago which could be is seen in your blood test it's uh more of the long-term exposure and what still is inside your body so what your body has

not been able to eliminate by itself and then that test will basically provide um information about all minerals so if you have any deficiency on any mineral we will know as well such as ion deficiency you know Iron markers from the blood are not really reliable um so it's uh difficult to know the exact deposits of the blood uh of the body ER of iron just by looking at the blood right can hair analysis so it's mostly for the minerals and then the heavy metals can it detect things like mold as well no no not

not for mold urine urine analysis that wouldn't go into your hair that would be urine yes but you can detect uh also radioactive uh radioactive elements such as uranium talium then the most common ones are Mercury lead uh cadmium titanium I can speak about them if you if you want to me to um there's also gold silver which you may be in contact with through running water uh since silver is used is used for many things and copper which which is an essential mineral but when there's too much of it it's toxic sulfur Trace elements

as well stonum Boron you can detect uh any any metal right so what happens if you start doing oh okay before that question what are the some of the maybe junk material or toxins that our body internally produces because as far as I as I as I've understood it it's not all that we need to get rid of the external pollutant and toxins but there are a lot of things in our body that needs to be also that are created they're like exhausted stem cells or things like that um such as sent cells yeah yeah

that tends that accumulates in every tissue and it affects the architecture and the physiology of the tissue and it Mak you makes you age faster so senescent cells are part of the normal functioning of the body and they are Essen poal for tissue healing and cancer prevention so in those animals that have impaired sence building mechanisms uh cancer develops more easily because in a youthful State they don't have a way to put a stop to Cellular division when the cell carries too many insults such as uh double DNA uh strand uh ruptures then that cell

mutates and can become tumoral so then instead of that the body has developed a mechanism to make it stop dividing um basically making use making it useless but in reality what happens is that longterm that cell keeps active although it's not dividing but keeps secreting junk it keeps secreting inflammatory cyto kindes and it keeps secreting pressence factors that affect healthy cells and then more and more cells become senescent eventually the generating the tissue and their and the function of the tissue so it's it is hypothesized that by reducing the burden of senescent cells of the

body we can extend the lifespan of every healthy cell every tissue and the lifespan of the stem cells that reside in every tissue let's say by taking care of the environment by not making it poisonous which is what sessen cells do in the long term once they have lost their initial purpose um we help the those ccent cells that were asleep that were like hibernating and were not aging they kept they were kept in a youthful State we help them activate when they need it and produce more copies of the tissue cells that are needed

to keep functioning so what is the risk of stacking longevity protocols if we don't do the detox the smallest risk you you could have is not achieving any result okay because by loading the body with antioxidants for instance which would be done in the third step in the Regeneration step or by loading it with NAD we won't solve what's causing excess oxidative stress we will just mask it or maybe it won't even be enough so nothing that we do will compensate for the damage that's still going on so without repairing that damage step three makes

no sense but in the worst case scenario step three could help in increasing the damage because we don't want want to overactivate mutated cells so we risk theoretically increasing the risk of cancer if we repair damaged tissues okay well how do you then detox the body okay so then phase two as I told you first the let's say the easy part would be to remove external toxins it's I'm saying easy but it's not easy at all but that would be the the most simple approach first remove heavy metals which can be done by oral and

IV culation so once I know once I have the exact profile of what the patient has accumulated whether it's Mercury lead or aluminium depends also on the symptoms of course because um you never treat the the test you treat the symptoms you treat the patient so if the patient clearly has brain fog fatigue memory loss uh impaired muscle coordination which are mainly symptoms of mercury accumulation and I see high levels of mercury in the test in the mineral test and I see high levels of aluminium or high levels of cadmium or other minerals as well

I will focus on Mercury then once we've removed these uh metals and these external toxins the other ones would be for instance microplastics which we know Sona sweating and physical exercise aerobic physical exercise help in in expulsing from the body the microplastics uh that can be done at the same time once we've removed as many microplastics and as many heavy metals as possible then we start with the on the Improvement of the internal toxins the internal toxic factors that affect us and that makes make us age uh faster such as ccent cells with senolytics with

xenomorphic which don't destroy senescent cells per say but uh block them and sometimes that's more desirable than using senolytics which destroy them because if you overdo senolytics you increase inflammation in the short term right and what are some of the supplements and protocols you use for this so first for heavy metals uh for inance L there's only one option which is IV culation we use Eda uh combined with uh lots of other ingredients uh such as procaine which is an anesthetic uh we use high levels of high high doses of Vitamin C which also have

a chating effect and that at those doses cannot be taken orally I'm talking 5 10 20 grams of vitamin C the the oral threshold goes up to 2 G which is the the highest concentration that's well tolerated so we go beyond that and for mercury you can use oral Kant scalant agents such as D MSA that's the most validated one but sometimes that's not enough and you have to combine it with IV culation as well then for the senescent cells I really like curcumin because it's a safe and effective xenomorphic that's been used for decades

and it it also promotes apoptosis of damaged cells so it will remove junk that's accumulated in your tissues and I really like quartin as well because of it has a similar effect but it also destroys uh sent cells quatin then there's fistin which doesn't have evidence in humans yet but it can be used orally and it's safe as a comp ment I think the reason why it failed to provide evidence in animal studies so far in extending lifespan is because it's uh really poorly absorbed it's a it's a lipid soluble flavonol so fistin in my

opinion is promising but it needs uh more research so to sum up fistin or was a complement and intravenous curcumin so termeric extract and quatin okay what about things like many people would choose like active charcoal or even clay once you have the toxins well my opinion is good and they have uh zeolite active charcoal have a lot of evidence but they're only useful while the toxins are still in your gut so for acute intoxications once they have been absorbed um they're useless all those uh absorbent agent absorbent agents also absorb vitamins and minerals and

nutrients so if you're taking them make sure you don't take them together with your other supplements yeah absolutely yeah like over consuming things like charcoal can actually then on a long term have negative sometimes people think that more is better but that's not the case yeah so we want to detox I guess take home message here is that we want to detox the right stuff and we want to preserve the nutrients that we want to like actually have our bodies absorbed and for this we need quite uh detailed and specific strategies for the detox to

Target that specific thing like for example the Mercury that we the specific things that point to that that's great that was a very good overview thank you um then the next step would be the Regeneration and with this I thought we could go through of the skin and hair you talked with Team quite a lot about the regenerating the cells in general and I know there is a like you came from the Cosmetic world world and there is like quite a big big request for this and I would think that there is almost the the

general Trend that I'm noticing is that skin is still thought to be sort of like yeah more of like the aesthetic side but still skin is our larg largest organ and it protects us from pollutants you told that it's a major absorption site for Toxin and pollutant so it's a it's a selective barrier it allows you to absorb certain things and it shouldn't absorb the bad things but for instance uh one approach I'm I'm kind of playing with now or um trying at the moment is um topical transdermal peptides okay tell such as such as

NAD for instance um so for patients that have tried intravenous NAD and oral NAD precursors and they still haven't reached adequate levels I'm now complimenting those with liposomal formulations which are basically like a serum that's applied into your most uh sensitive skin areas where the skin is thinnest like uh behind your your or in the anterior aspect of your forearm and then you allow for the for the transdermal absorption of pure NAD that's been encapsulated and let's see I hope it works not yet not yet I cannot I cannot provide any insight but it's promising

same thing what I what I do have tried and has worked so far on myself is the Delta wave peptide which is a Russian peptide that's uh applied this way transdermally and that improves Delta sleep so the the total amount of Deep Sleep Delta Sleep is the the deepest phase of sleep when you're most more unconscious so it should be at least one and a half hours I've never had a trouble in reaching that that threshold but I wanted to see if it works and um since my my partner was in Russia she's Russian uh

one month ago uh she could bring me that peptide in particular and I asked her to um and she brought it I tried it and see what happened and I could reach for the first time two hours 15 minutes of deep sleep oh okay by complimenting it which is amazing I felt amazing uh the day after it's at the expense of light sleep not of ram sleep okay in my case interesting uh was it your total amount of sleep was still the same now Total Sleep same same in total so about eight eight and a

half hours but the the Deep Sleep face lasted longer and then the short deep sleep faces that followed in between light sleep were more more frequent so you give the body um more time to repair and eliminate the toxins that accumulate for instance in your in your brain that's quite interesting is is this something that's currently applied in clinics regularly or is it still more of an experimental research based thing it it's still only for research okay but I think in in general Cas it doesn't carry any risk so if it hasn't become mainstream or

if it's not seen often in clinical protocols is because of uh um it hasn't been widespread it hasn't been it's not a knowledge that has been widespread we don't learn that in in med school we don't learn about peptides Even in our master's degrees so it's something that the knowledge is there but you need to research for yourself right so um let's discuss uh the skin a little bit what is what are the other principles of regenerating skin same as regenerating the body or is there something you know special in the skin I would assume

that all organs have their their own protocols to some ex then of course yes we we cannot compare regenerating the brain for example or helping the brain make its function which is an organ that basically has a extremely slow turnover of cells there's barely any newborn neurons in the adult phase um with the skin which is constantly regenerating or it should be healthy skin removes all of its external layers every 30 days whereas um heart takes uh I think about 18 years and the Brain lasts for our entire life and it barely regenerates um so

in the case of the skin I would say it's one of the easiest organs to regenerate but the difference in the approach is that we have to cause some harm to activate its regenerative capacity so what do we use usually we use peels we use chemicals we use lasers we use things that damage the external layers of the skin and as a response those dormant stem cells that reside in the deepest layers of the epidermis received receive um receive a stimulus and they activate the cell turnover they start dividing they produce new younger cells and

those replace the old ones and that's uh to me the best anti- wrinkle uh approach that we can have but um bear in mind that we need to cause some temporary damage first so you shouldn't overdo that yeah yeah for sure for me personally like I I suffered for years and years this very deep AR scars in my face and I tried all the creams and what not like H nothing helped until I started micro needling did you try by any chance um tretinoin creams retinoic acid not retinol um tretin tretinoin I I did try

it was very drying for my skin so so too drying I have I had so sensitive so fragile so thin skin at that point that it was only I started 0.25 needles as well and already together with together with needles no no no that I tried 25 micro needling you were talking about the death I thought you were talking about the concentration of the of the cream ah no no so after that cream I I thought that okay I can't do this so I started the micro needling and I'm like whoa what happens here like

my skin literally started changing so that's goes to like anecdotal evidence for the micro damage that is really essential for starting regenerate definitely that's that's a good way to to regenerate the skin and I use it usually at at the clinic for for acne scar for sta as well and for superficial wrinkles but for deep ones you need to use uh things that reach the dummies so not even with the with the deepest uh depth with the with the with the strongest Micron needling you could reach the Deep layers of the dermis so in those

cases it's preferable to use uh the so-called ablative fractional lasers such as CO2 laser which basically creates a column of uh microscopic column of uh temperature that reaches the bottom of your skin and burns it without burning the surrounding tissues therefore allowing for the surrounding stem cells to activate and repair and that same thing can be applied for acne SC so for instance if you want to use the Lesser invasive approach you can do 10 sessions of Micron needling but if you want quick instant results you can do one to two sessions of uh CO2

laser and you will achieve it in in one quarter of the time but you will have your face burnt for a few days and you'll have to take a lot of care yeah I actually did that once I did the CO2 laser it was quite it was quite a hard treatment I had a downtime of altogether four months I wasn't able to travel to sunny places and had to protect my skin a lot and um I guess I was effective but I still prefer the dermar rolling because it's something that's a bit more gentle but

yeah of course with the deep deeper scars it was maybe a bit more effective then uh what what do you think are the biggest things that are damaging our skin like photoaging is one what other things we need to do to protect our skin from aging and getting wind cold up definitely well first as I told you in 2021 I changed my focus I stopped working only on the external signs of aging and I would my answer back then my answer before 2021 would have has been probably uh avoid uh like creams that contain alcohol

avoid uh avoid silly uh creams with uh with silly ingredients um try to stick to the basics use a natural sunscreen As Natural as possible as without endocrine disruptors and use SPF 50 plus during the whole year not just in summer months Second Use a retinoic acid or another retinoid cream if your skin is too sensitive to retinoic acid which is the the most potent one the strongest one it's my favorite tool so if I had treated you a few years ago when you had the acne scars not now that you have this uh amazing

Supple skin Inca thank you I would I would have probably given you micro concentrations of tretinoin instead of starting directly with the Micron needling I would have started with the cream but at really small concentrations which can only be given by compounding the creams so you don't have commercial concentrations at 05 the the the lowest one starts at 025 which for some people is too much then after a few months I would have given you the micro needling and um parallel to that my new focus is in improving diet gut health and of course treating

biological aging so I would have given you the senolytics I would have removed your toxins the whole package at the same time not just treating the the appearance or treating the skin itself it's a more holistic approach but in the long term it's what provides the best results yeah let's discuss some of the supplements and the internal things that we need to do to protect our skin as well of course collagen supplements are one of the most known ones especially like collagen Tri peptide which I currently use and I've seen like major improvements compared to

when I was using the the like collagen peptides so way more potent um what other things we need to do internally to make sure that our skin gets nourished and Supple and anti-aging or regenerating let's start by understanding what happens to skin as we age and what skin loses it mostly loses in The extracellular Matrix its content in water due to loss of proteostasis because the the collagen fibers become entangled broken and they don't carry as much uh elasticity they don't they lose the the this El the elastic property they they should have and we

lose the hyaluronic acid from The extracellular Matrix that contains the water so collagen provides the elasticity so the ability for skin to get back to its previous position um with mimicking or with tension any sort of mechanical tension and hyaluronic acid provides it with hydration suppleness and H it also allows for inter cellular communication so without water without fluid cells don't receive messages they do they wouldn't receive them optimally therefore we need to improve we need to provide hyaluronic acid orally or intradermally not topically topically unless it's encapsulated which is something that's still undergoing research

I don't really believe any hyaluronic acid serum works at the moment it basically acts as a lubricant so it makes you feel good it makes you feel hydrated but once you wash your face you get back to your previous stage and therefore you need to inject it directly into the dermis that's done using the called mesotherapy technique which is Tiny needles that perforate the skin you make lots of tiny pinches all throughout your your face your neck or the area you need to improve and uh that creates like tiny pules tiny pimples um for a

few hours until the honic acid and the other vitamins and minerals that we inject dissipate in What's called the third circulation which is the dermis so it dissipates it extends and it reaches the whole area um orally hyaluronic acid has proven beneficial for both hydration and uh the aspect of wrinkles of the skin in several metanalysis um it's the effective doses start at 150 milligrams and it can be absorbed well but bear in mind that it's not the same treating you than treating a 70-year old a 70-year-old is going to need a lot more hyaluronic

acid and the body will not prioritize the skin so it will and the X amount that you give them first to the cartilage and last to skin and hair therefore I would give him probably 500 600 milligrams not 150 daily then apart from collagen which has been extensively spoken about and I think it's not worth uh it's not worth speaking about it today we have asanin and betacarotene and all carotenoids for that matter can help skin they act as a an internal sunscreen increasing melanite activity so producing more melanin and also reducing the oxidative damage

that accumulates in the skin either by aging itself or by photoaging caused by by Sun radiation so I think they are a a must have in your in your skin supplement protocol and my favorite is aazan um although it depends on the case in other cases it may make sense to supplement line and betacarotene but that converts into Vitamin A which accumulat and can become toxin whereas asanin does not so and asanin has more evidence in um human studies regarding skin and I I like it I like it also for its uh effects on uh

antioxidant uh capacity on improving the antioxidant capacity in the rest of the body and the I think it was the ITP study also showed that in animals it extends lifespan by around 20% in mice so I really like that for that I really like it for that reason too that's great H what do you do for your own skin what do I do well same thing I apply to to my patients uh so basically I use a tretinoin acid night cream with other ingredients it has at the moment I keep changing it depending on on

my appearance and depending on the time of the year but at the moment my current Formula also contains melatonin it contains dmae which is demethyl aminoethanol it's an antioxidant and it also provides elasticity and improves uh improves uh the the wrinkles it's uh it's as I told you it's it's a firming agent it it creates uh more tension in the skin it has 0.12 at the moment troin acid uh 0.2 I've been increasing it by 0.02% every six months for the past six years and I tolerate it well and I don't use it alternate alternately

I use it every day uh what else uh that's at night it has more ingredients I forgot about them now uh but but it's a really complex formula um which by the way I give to all my patients in uh the different protocols that I apply they all include a skin analysis and hair analysis with a personalized formula for skin and hair then during daytime currently I'm using the the French uh sunscreen brand svr which is a chemical sunscreen but it does not contain endocrine disruptors I find it more comfortable than mineral sunscreens but when

I go to the beach or I spend long time a long time outside outdoors I use uh Badger the badger brand which is a natural brand from the United States that only contains non- Nano zinc oxide and it's pretty heavy chalky chalky sunscreen but it's uh super safe for both you and for the ocean so I use it outdoors I crossed the the Sahara desert with that sunscreen and I came back as pale as I am now so oh wow okay yeah those pretty effective they make the white cast to the face but I know

like Surfers use that that's Badger is for surface actually yes yeah yes but it's it's too heavy to wear it on on a day-to-day basis so I use svr the SPF 50 plus creme mous that's my favorite because it's really silky to the touch it doesn't give you the sensation of wearing a cream it it basically you don't feel anything in your face so that's I think most men would like that yeah yeah I also know one other one which is the L Ro POS yeah I I used that one I love it I stopped

I stopped recommending it because I got pretty strong sunburns with it and I have a a few patients with malasma which have had uh relapses by using it but those are very specific cases and I don't know if anyone else that has had Burns using it so that's so it's not a bad sunscreen yeah it's one of those sunscreens that I run all the time as recommended ones in this longevity space so that's quite interesting but maybe I'll try yours as well but it only protects about you uh of from from UV radiation the anelos

uh anelos XL Ultra fluid I think that's its name that one lacks protection against infrared light and against visible light so it's a matter of concern for people prone to sunspots and melasma uh so I tend to recommend things that contain the whole the broadspectrum filters um SVA has them by the way I don't have any affiliations any affiliations or anything with any of these Brands I just recommend what I've tried on myself and my patients and and I've eventually liked uh but there's many other brands there's many other good brands for instance aen which

is also French has the agne prone skin supplement um skin sunscreen uh which is also natural and it does not uh contain endocrine disruptors and it has the the broad spectrum so um back to my routine uh apart from what I told you I have uh at the moment I'm having injections every three months in my hair of uh exosomes and PP and in my face I'm injecting vitamins minerals and hyaluronic acid and I'm willing to try exosomes in my face too but uh I'll combine I won't replace what I'm doing the moment and probably

I'll do like one session a year of exosomes to improve difficult areas such as the iids which are the ones that usually show more premature signs of aging right and have you noticed with this routin that you're doing have you notied a clear reduction of signs of aging I mean you're still pretty young so maybe you cannot see them that well not so much not so much but yes uh I can't complain really uh I have noticed uh have noticed uh I could tell you when I started almost 10 years ago my wrinkles in the

eyelid area were deeper and I haven't evolved any deep expression wrinkles although I tend to use my forehead a lot when I read and when I study I tend to do the the frowning gesture to uh concentrate better a lot and that's also an improvement not worsening is also an improvement since I'm almost 10 years older and I haven't used Botox on myself although I'm all for it if in the future I need it I'm going to use it yeah uh what is your view on the toxicity of Botox so I feel like there is

sort of like hate love relationship with botox uh going on in in the space which is like you know it's true you either hate it or love it it's yeah it's like like some people say that it's absolutely toxic and that will accumulate and you know that's not good where's the meta analysis that I found actually haven't found that much like harmful effects long-term effects of of falum toxin but there's no studies so far showing any proof of accumulation in the body and any signs of short or long-term toxicity when used in therapeutic doses so

first thing we must clarify is that it is indeed a toxin it is actually the most powerful toxin known in planet Earth but we must understand how it works and why it could be toxic in high doses so botolinum toxin is produced by clostridium botolinum which is a a strain of bacteria that um love canned food so when when you eat a contaminated can of uh meat for instance um that's that's expired long ago uh you may be eating around 2,500 to 3,000 units of Botox and that is going to cause paralysis of your respiratory

Center in your in your uh central nervous system and therefore you may die because you not you're unable to breathe but it's not toxic at a cellular level it basically interrupts neurotransmission of the acety Coline uh um synapsis so without acety Coline smooth muscle can contract and you stop breathing and you stop bowel movement and that's basically it so once we understand that once we understand that there's no accumulation as it of of toxins inside cells as it would happen with Mercury for example which accumulates inside your nerves and creates um neuronal inflammation and in

the long term it it can it can contribute in developing Alzheimer or other types of dementia H in this case botolinum toxin stays in the synapsis between neurons for some time until the body clears it out which is at between four to six months and I I guess this this point is uh relevant to inform any listener that now we are not talking about the neurotransmitter in your brain so as it the botox doesn't travel to your brain and prevent your neuroplasticity and memory formation so we are talking about the neuromuscular connection that is local

for where it's injected we use it where where where we need it so we inject it in the forehead muscle it will stay there it will block the neurotransmission only there it won't affect any other nerve so for instance it's been used in in children with uh paralysis in much higher doses than it's used in Aesthetics and without any reports of adverse effects other than weakness of the of the limp that's been injected obviously which may happen but it depends on the dose so I would say 30 to 50 60 sometimes 100 units of Botox

is perfectly normal for an aesthetic treatment up to 500 units is perfectly safe and it's proven safe for migraine treatments for muscle spasms for paralysis for urinary incontinence this the the list goes on and on this growing indications every day for Botox uh even uh for seate dermatitis for your scalp when when you secrete too much oil it basically blocks the smooth muscle inside your your oil glands from your scalp and it provides relief of the of the scaling and all of the itchy itchy symptoms that it produces so thank so much for for this

view because I really wanted to learn it or hear it from you and your opinion your Insight just because I know how much you appreciate the natural way and your whole approach is about don't get toxins in your body and and and you care about the cellular regeneration that um yeah what's the what's the sort of Mind definitely definitely and if I can avoid using Botox I'll be the first one to to do it but uh we must also understand that as we age our facial mimics the the exposure to repeated muscular tensions over time

develops into wrinkles that cannot be treated by any other methods so if if aging has made our forehead muscles too strong we need to address that with the right tool and in this case it would be Botox and for instance if we have developed a muscle contracture in our back which gives us a lot of pain every day because of our posture because of our bad posture or because of a um an anomaly in our SK in a skeletal um system for instance uh scoliosis can develop uh muscle contractures uh then we need to treat

the that excess strength that's causing the pain or that's causing that uh malformation in your back and that's the tool botex in in in that case has an indication as well yeah I've seen insane results with micro needling as well and dermarolling seems to also be because it thickens the skin right so Thal rolling it can give the impression of thinning the skin at first but it really thickens it yeah our skin atrophies so it becomes the the active layers of the Skins be of the skin become thinner and what becomes thicker is the dead

layers we accumulate lots of dead cells on top of the epidermis that's called corneal layer then what Micron needling or any any other mechanism by which we create an abrasion and a damage uh control damage on the skins for for example tretinoin or chemical peels or lasers is going to remove all that dead skin and create new cells so what there is available for hair so alope is kind of um very difficult to treat problem and how can so how can what causes let's say what causes uh let's say um Bolding like male pattern Bolding

female pattern hail loss and thinning during aging and is there something that we can TR to prevent and treated sure there's so many causes that we we could do an entire podcast about it but let's speak about the most frequent ones and the ones that affect us the most during aging so in normal conditions the most common causes of hair loss both male and female are androgenic alopa which is male and female pattern hair loss mostly contributed by uh sexual hormones either low estrogen or high testosterone but mostly high testosterone and more specifically high dehydro

testosterone which is the active form ER and the other one is telogen fluvium which is basically it should it's normal as long as it doesn't last for more than three to four months but there's lot of factors that contribute in making it Chic and it tends to affect more women because it also depends on the levels of of iron and women tend to be lower in in Iron tend to be to suffer more from anemia that's natural but that's something we must pay attention to uh when diagnosing uh hair loss because uh if there's any

nutrient deficiencies we have to address them as as again as I told you with skin the the body doesn't care that much about hair and skin if it has a heavy deficiency in one mineral ER that it needs to provide function for the the vital organs it's going to direct everything to the vital organs and forget about the hair so um main causes we've said hormones sexual hormones we've said Nutri deficiencies but also medications there hundreds if not thousands of medications that cause hair loss for instance I'll give you an example that you'll be familiar

with caline cine one of the most prescribed anti- anti-depressant drugs uh causes hair loss and it can be chronic uh what else antihistamines can cause hair loss virtually anamin antihistamines some some of the first generation antihistamines that some people take for for sleep and for ptis so itchiness anyway medications we must check what the patient is taking also heavy metals accumulated in the body accumulated in the hair other toxins that we don't know um aging itself that's called that's called scile hair loss scile alopecia that's the I would say most difficult to treat but by

regenerating the hair follicle providing it with exosomes providing it with growth factors we can again switch on the dant stem cells that remain there if we take care of those we can extend the the lifespan of the hair and the and its quality so make it thicker and with hormones yes yeah how does the exosome treatment for the hair look like how does it look like it's injection same same way I would inject uh I would inject vitamins in in your skin I could inject exosomes in your hair they come in loped vials so it's

it's very simple it's very easy for the patient there's PRP as well I like both PR works better in younger people and it's more affordable than exosomes so in your case in my case as I told you I'm using PRP although I'm also using exosomes because I have easy access to them um I can buy them directly to the to the lab for uh so I I cut the the doctor's the doctor's costs if I inject myself so I I combine both and they provide different profiles of growth factors but for a young person that

is otherwise healthy I would say PRP works very well especially for telen fluvium in women in men if we want to treat the androgenic alope we must address hormones in any case in women we don't need to because there's not such a clear relationship in every case so it's more of a trial and error approach if we try PRP and it doesn't work then we may try with some hormone blockers or we may try with some uh estrogen drops that you apply in your hair together with Minoxidil which increases blood flow so a basic protocol

for a male pattern hair loss would look like this first thing stimulate blood flow with a topical solution of minoxidil and then block DHT either topically which doesn't have any side effects with the same drops you can apply the the drugs that block it such as fasite or tasterite and it has some effect it's not super effective in every case but it may help when you're very young and you still have a lot of hair then the second line of treatment would be injecting not hexosomes not PRP at first but this DHD blockers combined with

vitamins and minerals directly into your hair follicle to help it grow and on top of that you can add PRP but that's complementary for men and then the third line of treatment that's the one that's that's proven most effective but also with the most those effects is the oral treatment with both minoxidil to increase blood flow orally and to tasterite fasite to block theht that has unintended consequences I try to avoid that as much as possible but sometimes there's no other way and it always will depend on how important how how much importance the the

patient gives to to his hair loss problem right what's what's your opinion or or um like experience on some of the nf2 activators that also were popular at least at one point like kumine suoraan Resveratrol they effective probably any Nrf2 Activator will help because the way DHT damages the follicle in androgenic alopecia is by increasing the amount of reactive oxygen species so any antioxidant for that matter either through the Nrf2 pathway or through direct antioxidant effect is going to work uh but I don't use them with that purpose I have I don't have experience using

those I would say I usually use uh in my in my topical formulas antioxidants such as jinen I use uh like Joba as well those have some evidence but we can use more complex ones such as melatonin which I love you may know that already I use it in my in my face so why not in my hair as well yes I apply daily nightly minoxidil drops that contain melatonin because it's proven to extend the anagen the growth phase of the hair by protecting the cells from reactive oxygen species and with with melatonin unlike with

other antioxidants you don't run the risk of overdoing antioxidant it's not like vitamin C or like uh aanin so it acts more indirectly uh increasing it go it works through the Nrf2 pathway actually same as sorane so it's an indirect pathway and let's say that there's a funnel to it it's its effect if you give a lot of it it's not going to provide too much antioxidant effect okay so when it comes to hair it's like it should be as well as with with the skin would you say the the most effective approach is to

combine the internal regeneration and the topical and focal treatment yes uh in terms of supplements for hair I would that would be secondary so I would pay P attention to diet I would make sure the patient has uh doesn't have any leaky gut issues and he absorbs well any nutrient um and I'll make sure he or she eats well and eats plenty of Whole Foods and if that's fulfilled there's no need empirically this it's it's usually done but there's no need it's there's no proof that giving extra vitamins and extra minerals in supplement is going

to help your hair grow more or fall less so that's secondary and it's I use it on a trial and error approach so I will focus on a good diagnosis and see if it's a teligent fluvium uh increase growth by any means PRP minoxidil topically orally injected I can inject uh vitamins and minerals but that's also secondary I will I will focus on injecting uh for instance melatonin if I suspect if the patient has an autoimmune disease that may be contributing to uh more hair loss then I will inject melatonin in in their hair to

reduce local inflammation and then if it's a male or female pattern hair loss I will try to bring the the DHT levels down to a more stable level that does not cause hair loss but that does not develop any adverse effects such as loss of libido such as um loss of physical performance or fatigue or any of the other uh side effects which I would say the worst one is uh development development of mamory gland in males it's very rare but uh it's been reported and no one wants that so um I'm the first one

to avoid it as much as possible and to use it with caution thanks so much Alexis this has been such a great overview on all of the skin regeneration hair reg generation uh now if someone is like okay I'm so inspired to start treating my skin hair and Longevity and regenerating myself what would be like one of the advice that you would say like okay start with this today mm start paying attention to your diet start paying attention to your habits mostly your sleep your levels of activity try to focus on that and optimize that

before entering more sophisticated strategies and before uh supplements and before any Medical Treatments and once you take once you once you have the healthiest lifestyle possible you can have on your own then seek help to go the extra step to take the extra step or go to the next level yeah and detox the body detox the body yes drink a lot of water definitely practice Sona if you have any available nearby uh practice lots of physical exercise doesn't matter which type as long as you keeps moving your body and sweating uh uh sleep well focus

on sleep I would say organize your day according accordingly so so to guarantee a really good night sleep restful high quality and long good night sleep and what else and then be careful be mindful of sun if you want to keep a youthful appearance in the old age and take take care take use sunscreen every day and that doesn't mean you cannot spend time Outdoors of course you must spend time outdoors and receiving sunlight is healthy but uh protect your skin and maybe in that sense you can already start supplementing with Estes antin and other

carotenoids as a compliment to your to your sunscreen great and um please Pro provide the links on your web page to your clinic and to your Instagram and social media sure well um I'm on Instagram my Instagram is Alexis Orga with a lower hyphone MD with another low of hyphone and there you can you can follow me and I publish a lot on longevity strategies uh on what I do at my clinic on my protocols both for as Aesthetics and for um prevention preventive medicine and you also have my my Clinic's website is www aastra

clinic.com thanks you can yeah go go follow on Instagram it's like it's such a good information you have a very nice infographic post about different aspects of longevity so I feel like I'm following you I learn something new every day so thank you that's a great compliment thank you so much