What Happens To Your Body If You ONLY Drink WATER For 100 Hours?

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Dr. Sten Ekberg
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Video Transcript:
Hello Health Champions today we're going to talk about what would happen if you did a fast and you had nothing but water for 100 hours and why did I pick 100 hours because it is a nice round number I like the number and it's approximately 4 days it's just a little bit over 4 days and that's a time of fasting that most people could do very safely if you don't have any health problems if you have something going on check with your doctor but most people can fast for 4 days without really changing a whole
lot and we're going to talk about some of the things you want to think about and if you fast for four days you get the vast majority of benefits of doing a longer fast and with longer fast I mean more than 24 hours and if you go on to about 4 days or 100 hours you get virtually all the benefits that you could get from a longer fast and these benefits include things like autophagy which we're going to talk about in detail you get a significant drop in insulin you get a significant boost in immune
function you even get some Stem Cell Activation and you improve your biome your microflora the balance and quantity and you get some gut healing so we're going to talk through what happens on each day so you really understand what the benefits are and what's happening in your body so from 0 to 24 hours it's what we call the glycogen depletion phase this is where you go from a Fed state where you have eaten to where you stop eating and now your body starts using up the glycogen and glycogen is stored carbohydrate it's just the form
that your body stores extra carbohydrate so when you eat your body breaks it down to glucose and then it starts linking it up into branches of glycogen and you keep most of it in your muscles but that glycogen is air marked for the muscles that can never go out in the bloodstream again and become fuel for the brain so what we're talking about is the glycogen in the liver so when your blood sugar drops now your body can release that glycogen from the liver and Supply the brain and other tissues that need glucose so your
energy source in the beginning is going going to be mostly glucose as you break down the glycogen but gradually it's going to shift into fat and sometimes when people talk about this it sounds like in the beginning you're using 100% carbohydrate which is not the case because even if you're breaking down glycogen for blood glucose and your brain is using virtually only glucose at that time if we go on a scale from about 100% to zero and this this here is about 10 and this here is about 90 then we start off at about 50%
of glucose and 50% fat and then as we go as we start breaking down the glycogen now the glycogen is going to go down and the glucose usage is going to decline whereas the fat usage is going to increase so that once we're well into this fast we're going to be using about 90% of our energy from fat and 10% from carbohydrate or glucose and toward the end of The 100 hours we might actually be using as little as 5% of our energy from glucose and about 95% from fat and there's a reason for that
which we're going to talk about when it comes to hormones there are three of them that are going to change significantly and that's glucagon cortisol and insulin and glucagon is the hormone that breaks down glycogen our stored carbohydrate so that we can make blood glucose out of it then next we're going to have cortisol it's going to go up slightly because cortisol stimulates gluconeogenesis which means making glucose from other sources such as glycerin which we'll talk about and from protein from amino acids and we're going to talk about about that in some detail so you
understand why that doesn't happen very much and insulin is going to drop dramatically because the purpose of insulin is to get glucose out of the bloodstream and if we're fasting we're not adding any large amounts of carbohydrates or glucose we're only maintaining a small Baseline and that Baseline is going to drop over time plus we're going to get more insulin sensitive so we need less and less and there's going to be a drop of blood glucose over the course of the 100 hours and the reason we're very interested in lowering insulin is that it is
responsible high levels of insulin are responsible for insulin resistance and type 2 diabetes and fat storing which is affecting about 80% of the world's population and it is the central issue in most disease most degenerative disease in the world today we're also going to talk a lot about autophagy and during day one this is toward the end of the day it just starts ramping up and why are we interested in this because this is one of the biggest reasons that we do a fast because autophagy means self-eating and if you don't add any new resources
to the body the existing resources become very very precious especially the building materials the fat kind of has the energy taken care of for as far as a reserve as a resource but protein becomes very very precious we increase the recycling and the cleanup so we're upgrading everything in the body that can assist in that process and some of the things we're recycling are dysfunctional proteins and cells so cells and proteins and building blocks and things that are getting a little old and worn and Rusty and decrepit now we start going out and finding them
and breaking them down and reusing them to a much higher degree than we would normally if we just get more protein through food autophagy is also going to improve our immunity and it is part of cancer prevention because cancer cells are some of these dysfunctional proteins and cells that we start Recycling and deep states of autophagy have been found to be able to break down and reverse some types of tumors and Cancers and we also want to talk about how our symptoms or how our experience changes through the 100 hours so in the beginning we
are naturally going to be hungry we're going to have some Cravings because the body is used to certain things and if we change things up it's going to wonder where did they go let me have some of that so we could also get some fatigue right in the beginning when the body doesn't know where the energy is going to come from when we're shifting our metabolic Pathways the body kind of has to relearn and we might have some fatigue you can also experience some Li headedness you could experience some mood swings some headaches and we're
going to talk about some things that you could do to minimize these symptoms because for some people they can be very severe where it's difficult to fast and for other people it's not a big deal at all but if you know what to do then you can absolutely minimize them and now we're into day number two 24 hours to 48 hours and this is the ketosis phase now ketosis it's started toward the end of day one but now it's really starting to ramp up and when it comes to the energy source on day one we
were mostly using glycogen for blood sugar and now most of the glycogen is gone so we have to get much better at using fat so the body is going to use primarily fat from this point on 90 to 90 5% like we talked about now the brain is a little different because it relies mostly on glucose in the FED state but as we get further into the fast now it's going to be a mix of glucose and ketones and it's going to change the further we go as for the hormones the insulin keeps dropping like
we talked about but there's a new one here human growth hormone is starting to ramp up drama dramatically and during the 100 hours we're going to get an increase of about 3 to 500% so this isn't necessarily during day two but during the fast we're going to see those kind of levels and the two things that growth hormone does that we're interested in during a fast is of course it helps us burn fat which we need to generate energy but it also preserves muscle so that we don't burn down the muscle to make glucose which
is super important if you're going over a day or two because you don't want to lose muscle just because you fast I'm going to talk about some reasons why humans are really really good at this better than any other animal and along with human growth hormone we also see a dramatic uptick in bdnf brain derived neurotrophic factor and neurotrophic is the key word here that's like Miracle Grow neurotrophic means it grows brain tissue it helps expand and generate brain tissue and these two hormones the human growth hormone and the bdnf together they help with neuroplasticity
so whenever we learn something new whenever we change a habit or learn a skill or adapt to something we have to make new Connections in the brain called synapses and without these two hormones we can't make those synapses they're absolutely necessary for for us to connect things so when they go up by several 100% that means our ability to learn and adapt increases dramatically we also get a slight increase in epinephrine or adrenaline which is going to help us generate some energy and to stay alert we talked a lot about what autophagy does so I'm
not going to cover that in detail but during day two it continues to accelerate it goes into deeper levels of autophagy and we just continue to clear out dysfunctional proteins and cells the symptoms and experience changes a little bit here because now with the increase in ketones we have a different source of brain fuel so now a lot of people who have had some brain fog they're going to see that diminish and also the hunger hormone gin which had been rising during day one because we stopped eating the body says hey go eat something so
makes gin to try to get us to eat so day one is kind of the worst day in in terms of hunger in day two we've gone longer so hunger is still going to be there but the body is realizing that hey you know we don't want to just abuse the poor guy and and stimulate his hunger if there's no food around so even though we're sort of have have some Hunger the Gin is going down now which reduces the hunger you could also start seeing some mild coldness in your extremities in hands and fingers
because your body is trying to save on energy save on resources it realized there's nothing new coming in so let's reduce expenditure just a little bit but that's a temporary decrease and a lot of people are worried about ruining their metabolism by fasting too long but you're not going to do that in a four or even seven or 10 day fast but if you go like three weeks or more now you could start creating permanent changes and possible damage to your metabolism and your Energy System but when on day two when the body is starting
to conserve some energy it's temporary and a lot of people during day two are going to experience increase mental Clarity and focus and a lot of that has to do with some of the stress hormones that we're releasing like the cortisol and adrenaline but primarily because ketones are going up and that's an alternative and even a better fuel that burns cleaner and we have less oxidative stress and inflammation in the brain now on day three everything continues so now we are in full ketosis and in even deeper states of autophagy and the energy source is
basically all fat and in the body we store fat as Tri glycerides which becomes very very significant and we can break down this fat different ways so we can get fatty acids out of it which we can use for energy we can get ketones from these fatty acids we can chop them up and put little units together for ketones that we can use for brain energy and we can even generate some glucose from these triglycerides so when we store fat we store them as triglycerides which is very very significant because there is a portion here
called glycerin or glycerol and it has three carbons in it we call that a backbone of the triglyceride and then the body when we store them we attach fatty acids to this so they're like little Tails so this component this unit all together is called a triglyceride where here's the glycerol here's the fatty acids so these we can use for energy at nine calories per gram and we can turn these like I said into ketones but this is three carbons and glucose has six carbons so if we take two of these we can put them
together into one glucose molecule so as it turns out the way we store fat we store 5% of the triglyceride can be converted into glucose and 95% becomes the fatty acid so a lot of people say you can't make glucose from fat and what they mean by that is you can't make glucose from the fatty acids that's impossible it's a one-way Street you can make fatty acids from glucose you can't go the other way but you can make glucose from glycerol which is part of the triglycerides and this is very very important it's been key
for human survival and we're going to talk about in a second how it's allowed us to have the biggest and most powerful brains in any animal in the world so now these fatty acids are going to provide the majority of energy for the whole body so all your body all your cells all your organs in general are going to be using these fatty acids almost exclusively the ketones are going to go to fuel your brain there are some other tissues that can use them but this is the primary mechanism the purpose of making ketones is
that it's the alternative powerful backup fuel for the brain and the glucose is going to also go to the brain but it is mostly earmarked for some tissues like red blood cells who can only use glucose they can't use fat or ketones so these ketones are pretty remarkable in how they allow us to adapt because even though we're going to have a drop in blood glucose during the time of the fast we might be starting at 90 or 100 and during the 3 to 4 days will probably drop down to 50 or 60 and if
you measure blood glucose in Mill moles then you just divide by 18 but you're going to have a drop of probably 30 to 40% and despite this we can still maintain stable brain function thanks to these ketones and together with the reduction in oxidative stress because the ketones burn cleaner now that's part of why we get some improved mental Clarity and focus but the ketones are also one of the biggest reasons that we get minimal muscle breakdown that we don't need to break down muscle to get glucose because we already have 5% stored in the
triglycerides that we can use very effectively for brain and red blood cells and a few other tissues and this is the factor that has allowed us through Evolution as humans developed to develop the big brains that we have it would not have been possible without the ability to switch to ketones for fuel so just to give you an idea of how this changes during the 100 hours if yellow is glucose and the pink is ketones at time zero this is how many percent of the brain energy that's derived from keto tones so when we start
we're in the FED State basically 100% of the fuel for the brain comes from glucose but already 12 to 16 hours in and if your fat adapted if you're on a low carb diet this is going to happen sooner and if you're going from a high carb diet then this may not have happened already it might take a little bit longer but 10 to 20% already from ketones and then after 24 hours we might be up to about 30% then after 36 hours 48 hours 72 hours and 100 so 3 to 4 days in we
are getting about 34 most the vast majority of the brain energy now is from ketones and very interestingly this ability to store body fat and then break it down and use it for brain fuel is unique to humans and bears and humans do it because we have such huge brains and the bears do it because they sleep for months but all other animals pretty much are going to have to have smaller brains they're going to have to keep eating or they're going to almost from the very beginning of a fast start breaking down muscle to
turn into glucose because their brains can't run on ketones or to a very very slight degree and this may be why there's this notion that fasting hurts your muscle mass that you start breaking down muscle very quickly but humans have a bypass mechanism that works very well for us but now during day three autophagy changes a little bit because at 48 to 72 hours it peaks which means the portion of autophagy that is about the recycling about retrieving resources it has its highest level it doesn't mean it's over it's just that's the highest level and
then from then on it goes more into the repair process and the Rejuvenation process of tissues and now we see a drop in inflammation we see a drop in oxidative stress and in inflammatory cytokines so these are the chemical Messengers that signal inflammation and we also get get an immune reset we're recycling the white blood cells and then we start making new ones that are rejuvenated they're younger so it's like we're freshening up our immune system and we're also seeing an increase now in stem cell production which is the cells that can diversify that can
differentiate and become different things so you have liver cells you have skin cells and you have all these different cells well the stem cells can be become it's an early version that can become any of those things so if you want to do a deep repair then and Rejuvenation of a tissue that's when we want stem cells and they start to really kick in here at the end of day three and as far as brain health we talked about the bdnf the Miracle Grow and the human growth hormone that we need to make synapses and
they keep increasing pretty much throughout the four days even though they've pretty much plateaued at their highest level so this further allows neuroplasticity learning and adaptability so a couple interesting things about your physiology on day three is that now you're in deep ketosis and there's different types of ketones there's one called beta hydroxybutyrate which is the one that you use for energy mostly but there is one also acetone is another Ketone but you're mostly just breathing that one out and as a result because these reach pretty high levels now you can have what's described as
a fruity breath and if you measure something called the glucose Ketone index meaning you measure your glucose in Mill moles you take milligrams divide by 18 and then you measure usually ketones in Mill moles if you divide the two then at this point by day three you're typically going to have a ratio about one which means there's as much ketones as there is glucose in the blood at any given time and we talked about you could get some mild coldness in extremities on day two and three and this is also that it's possible to get
some electrolyte imbalances become more significant and as a result then you could get dizziness and muscle cramps and lightheadedness and so forth but what most people experience at this point is that because you're ketones are getting even higher then your brain fog is going to reduce further the Gin keeps going down just like day two but now you really kind of pass the hump that on day three a lot of people really don't feel any hunger at all if they feel something it's usually because of electrolyte imbalances where they feel a little dizzy or lightheaded
most people are going to see an improved mental Clarity and focus and some people are even and report a feeling of lightness or Euphoria and Euphoria is kind of a state of bliss it's where you're feeling really good really joyous for no particular reason and now on day four we said that autophagy Peaks at the end of day three so on day four it's actually going to slow down a little bit it doesn't go away just a little bit less and now the body shifts more into repair and now during day four the stem cells
keep increasing and supporting this regeneration and deep healing so we get an immune system Rejuvenation the old white blood cells are replaced with younger fresher ones and we get tissue healing at a very deep level and one such tissue that can heal is in the gut so a lot of people have problems with their intestinal lining and leaky gut so this can be greatly helped by fasting and especially there's a nutrient called zinc L carnosine that has been shown to assist and support this process very very powerfully and we get a significant increase in cerin
gene activation and cerin are genes that promote DNA repair and Longevity so there are some anti-aging benefits here and the human growth hormone also keeps increasing during day four and of course like we said it helps prevent the muscle loss so it allows us to feed the brain without sacrificing muscle and human growth hormone along with the cerin both support anti-aging and Longevity and usually a lot of people will see a continued increase in mental Clarity in energy and stable mood they feel a very deep calm and some more possibly of this euphoria that I
mentioned also a big reason a lot of people do fasting is to R reduce systemic pain and Joint inflammation so a lot of people are going to see shoulder pain and knee pain and back pain go away at this point also and for the ones who make it to day four they're going to usually experience very very little hunger the body really doesn't signal hunger anymore at this point but there are also some potential risks and considerations that we want to keep in mind and basically the rule is if you don't feel good then stop
e something or at the very least have some salt or some electrolytes and then if that doesn't help then you start eating and go back to it maybe try later so one thing we talked about is electrolyte imbalances and that is probably the biggest risk or problem that we face with a longer fast and if we get electrolyte imbalances then we could experience dizziness in some cases even heart palpitations or fatigue we could experience orthostatic hypotension which means that your blood pressure drops when you stand up so you could get Li headed or even pass
out and that's from a couple of different things it's if your adrenals were a little bit weak to start with they can't increase the blood pressure fast enough when you stand up and now during a fast if you've lost some electrolytes there's not enough fluid for the blood vessels to squeeze around if you're flu fluid level has dropped because of electrolytes now it's harder to keep that blood pressure up also and you could experience some cold sensitivity like we mentioned which could be unpleasant but not necessarily dangerous for a reason that you have to stop
but I wanted to mention the muscle breakdown also that we have so many mechanisms that we've talked about the human growth hormone the ketones as a reserved fuel that it doesn't happen much however there's a couple of times that you want to watch out for it if you're already very thin your body doesn't want to break down fat if you don't have much left of it so if you're thin you have a low body fat percentage then it could start going after the muscles sooner and also up to 100 hours you're pretty safe but if
you go longer than 100 hours and you're thin now that could be a problem so keep that in mind if you're thin then you could probably fast up to 100 hours and if you like to have even more fasting benefits then you can repeat a 100h hour fast maybe every couple of months or every three months or something rather than doing a even longer one so there's a couple things you want to do to minimize discomfort and problems and risks and one is to get fat adapted first first so the whole thing during the first
day is that you go from a carbohydrate or a mixed fuel diet from glucose and fat into almost all fat but if you've already taught your body how to burn fat how to burn more fat than carbohydrate now you're halfway there it's not going to be a very painful transition and the easiest way to do at least part of that at least get part of the way there is just to eat a low carb diet for 3 to 4 days before you start the fast and low carb would be less than 50 or less than
30 grams of net carbs per day and the other big thing that happens is we call the first day the glycogen depletion phase but if you're fat adapted then you're already much much better at using glycogen you use it way more efficiently because you don't need it as much it's more of a backup than a primary resource because if you're fat adapted you're going to use mostly fat anyway you're already going to be at 70 80 90% fat usage and then your body doesn't need the glycogen and the glycogen is going to last much longer
but because you're fat adapted you're still going to get into ketosis faster so that transition is going to be so much smoother but perhaps the most important and the easiest thing to do if you're going to fast over 24 hours is to supplement with electrolytes the most important mineral electrolyte you want is sodium and then after that you also want potassium magnesium and calcium so sodium you get plenty from table salt so when you eat food you always have enough sodium if you salt enough but then the others could be more questionable and then when
you stop eating all together now sodium is the most sensitive it's the one that gets flushed out first but when I saw that there was a lot of people fasting and a lot of people had issues with electrolytes but also the fact that there wasn't really a good product on the market I developed one specifically for fasting it's like your fasting companion it has all of these in it in very specific ratios but I also put in trace minerals which is a mix of all the other minerals that you need in smaller amounts but I
really wanted to put in a couple of things to really support all of the processes that we've talked about in this video so I also added manganese bisglycinate and zinc L carnosine and the ending here means that they are bound to a protein to an amino acid and that makes them what we call chelated so with that they're easier to absorb and they have a higher bioavailability so I made this powder so that the dose for normal everyday use you could just take one scoop a day and it's a little bit low in sodium because
normally when you eat you get enough salt like I said just from salting your food but when you fast you want to take a lot more during the 4 days you want to probably go up to 4 Four Scoops a day if you're a larger person or maybe two or three scoops if you're a smaller person and that's going to make sure that you get a good amount of all of these things that we talked about and your fasting experience will probably be vastly improved but let me just elaborate a little bit on the zinc
El carnosine and the manganese bis glycinate that I put in my product you like because they're pretty fantastic nutrients the zinc ELC carnosine supports immune function and gut repair and especially the gut repair it's been studied to do and this is something that's already happening during the fast with autophagy and these Deep Repair processes so if we can add some nutrients to assist it now we can get even better fasting results this version of zinc enhances autophagy it supports the bdnf it makes these possible it accentuates it and and it's necessary in some cases for
these to function and the manganese bisglycinate is involved with metabolism it helps balance glucose utilization and it is needed for fat burning furthermore it increases antioxidant production inside the mitochondria and your mitochondria those are your energy centers your energy factories if you will and because that's where the energy is produced that's where you have the most oxidation that's what we do when we make energy we oxidize the fuel so there's a lot of oxidation and sometimes we describe it as Rusty and polluted inside these mitochondria so something that happens during autophagy is that we get
rid of just like the white blood cells we get rid of the old ones and we make new ones so we do that with mitochondria also called Mito Genesis and if we add this manganese bisglycinate now we can improve that antioxidant activity inside the mitochondria and make them burn even cleaner and the manganese also supports connective tissue which means joint and bone health which is something else you're repairing joints during your fasting experience but don't take my word for it give it a try and see what it will do for you if you enjoy Eno
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