Peptides For Brain Optimization, Composition & Longevity With Ryan Smith

foreign everybody Welcome to the muscle intelligence podcast peptides have become a massive thing in the Health Community most of you I hope have heard of peptides at this point peptides are short chain amino acids anywhere typically from three up to 100 amino acids in sequence and these different amino acids code for different things inside the body and today's guest Ryan Smith is one of the top three experts in the entire world on peptides he is the CEO of tailor-made peptides basically Kentucky now actually gone worldwide and this company is doing incredible things and I'll tell

you Ryan is an absolute genius when it comes to understanding the biochemistry and the impact these peptides are going to have and and let me tell you peptides are nothing short of remarkable they're certainly the most they seem to be the most tissue specific treatment modality that exists meaning a lot of things we do like hormones or medications are systemic they can affect men different tissues whereas the peptide you can really really isolate particular tissues as Ryan so eloquently explains in this podcast you're going to want to listen to every moment of this podcast because

we get into some really interesting ones I'm sure sometimes as you've never heard of I'm sure some that you maybe have and some that you definitely want to hear about you know this podcast with Ryan Smith [Music] Ryan Smith thank you so much man you guys are doing amazing things I had the pleasure of meeting you at the peptide conference this year and uh you know been following ever since and following your company and really everything in the peptide space because it seems to be perhaps the most exciting or one of the most exciting areas

of technological advancement when it comes to the human body talking about peptides thank you for joining me appreciate your time yeah thanks so much for having me happy to uh spread the word on peptides yeah I was picking your brain a little bit before we got rolling here and we got talking on the things that are most fascinating to me right now and as you could maybe speculate by the the name of the podcast it's muscle intelligence and the two things that I'm most fascinated in with are muscle head and intelligence starting off talking about

the brain stuff because there's a lot of really interesting things that exist and I think most of my listeners by this point are probably aware of what peptides are and how they work and for the most part I've had a number of other guests on that are in the peptide space but you know diving into some of these um kind of best practices around brain health you know as we age we know that our brain is slowing down we know that we're we've had less mitochondria and many people have some some traumatic brain injuries whether

concussions or whatever I'd love to just talk about some of the things you guys have discovered and how they seem to be helping people you know almost turn back the clock when it comes to their brain yeah absolutely you know you mentioned two things there which I think are are really uh important to separate out just because there are so many different topics but mitochondria in terms of mitochondrial function there's so much that that has been done in the peptide world and the small molecule world to treat mitochondrial dysfunction and how that relates to you

know a lot of different Health deficiencies but then the second one is the neurological approach we have just a ton of peptide products which are used to uh to help with mental functioning or cognitive decline I would say it's one of the really really strong area peptides just because a lot of these things have blood brain barrier Transporters a lot of them are small molecules that easily penetrate the brain and have some really effects very cool man so you know peptides to to my um recent surprise I've been around really since the 60s and and

the gentleman out of Russia Dr Vladimir cavinson seems to be the one who kind of pioneered the use and you know he's maybe got patents I don't know if you can patent the peptide but at least some Seattle seemingly some patents on some of these these peptides and uh you know he's been applying it to people for effectively 50 years now and see some really incredible long-term data can you just share some of that and just because I think it provides credibility to the topic yeah absolutely so peptides have been done you know uh really

since around 1901 they discovered secretin which is the first uh you know hormone in the human body that they sort of Discovery as a peptide since then you know things like oxytocin uh you know all those are peptide molecules or you know even the pharmaceutical program which are peptide lymbetics have been used in clinical practice and so uh the peptides just as a as a type of therapy are are have been used for a long time but are just now exploding and the reason being is that um usually the peptide weaknesses are really two things

uh Half-Life in the body mechanism the root Administration you know most of these things are injectables and so pharmaceutical companies haven't thoroughly investigated them because they have short half-lives and they are injections and so uh that's really hard to commercialize for a lot of these products but um as we've developed and you have a scientists relatively new um I mean they didn't even have a lot of these growth hormone secreted dogs uh they didn't have receptors for them you know they had the actual product the new it was increasing growth hormone and so uh now

the science is getting better in the last 10 to 20 years we've just seen an absolute explosion in peptide development so right now it's a leading area of just pharmaceutical product development in the U.S as of 2016 only eight percent FDA group products for peptide they anticipate that being around 40 over the next uh 10 to 15 years and so just an absolute explosion you know Dr cabins definitely led the way especially with a lot of these neuroceptides you you obviously mentioned at the talent that's probably the one that he's most well known for the

epithel under epithelium it goes by a couple different names but he's definitely done a lot of work and done a lot of extensive work the world of peptides you don't often see 15-year follow-up studies but you definitely have some of those completed you know it's uh Russia's been a hotbed for a lot of the products uh C-Max and c-link as well so Russia's been great but the United States is quickly catching up with a lot of new development super interesting so one thing I'd like to clarify that I don't think anyone's ever really explained is

you know peptides are almost as end product right so your body will initiate Gene transcription to produce an enzyme or a peptide that that initiates some type of response in the body so that's kind of the end product and some peptides work that way is there any peptides that actually work at the gene level to initiate the gene to create more of the peptide itself or is it usually one mechanism yeah definitely both mechanisms you know uh one of the one that we use a lot with mitochondria we have the motsc the mot C is

actually produced in the mitochondrial genome but actually then is taken to the somatic genome to change expression yeah there are a lot of different mechanisms for peptides in the body but they're definitely intracellular communicators it's definitely the best way to say it and then obviously the larger larger Pythagorean the proteins with secondary and tertiary configurations which have a lot more features in the body usually these are are anywhere prepare Karen and endocrine type signalers but you even have some autocrine type response with a couple things as it relates to you know even senescence and so

so yeah they're all used all over the body in a variety of features one of their best features though is just their specificity well these small molecules you get a lot of different results all over the body but with the peptides you get very very precise signaling and you also get uh you don't have to worry much about drug to drug interactions because you don't have to worry much about liver or kidney metabolism as much there are definitely some exceptions so that is the sort of the benefit of peptides is that they uh they're you're

just mimicking your body's natural configurations to provide the closest uh thing to stimulation and manipulating certain Pathways uh medically to sort of correct any type of deficiency that makes a ton of sense and the reason I asked the question is it seems as though you know if I take testosterone as a hormone we know it's going to shut down that system and I'm curious if taking a peptide would also have the same effect and then conversely if there's people studying this idea of well instead of just taking the peptide directly if we could take something

that's almost the secret of God like you say causing that Gene to transcribe more of that peptide would there be kind of a different maybe a better long-term benefit or different long-term benefit yeah you look at uh you know growth hormone is a good example because if you were to dose exogenous growth multiple alarm there's really no negative feedback with your body sort of loses control because it's sort of an overwhelming Cascade growth hormone goes to your liver produces igf-1 igf-1 creates bulletproof events you know the this criticals are a little bit different by encouraging

your pituitary you still maintain a lot of those negative feedback loops and so your body's sort of able to self-regulate it's not coming in with a hammer it's coming in with a scalpel right definitely depends on the path whether you're trying to work with talking about endogenous production the testosterone you'd obviously decrease your LH and FSH but if you take something like HCG for instance you don't necessarily decrease your LH even though it's mimicking that Alpha subunit of HD it's mimicking LH and so um it sort of allows your body to maintain a little bit

more maintenance and control which is the way to do it because our body operates in a very smart system um and uh you know to optimize it we just need a little bit of input not a lot man you brought up a Hot Topic so I got to go there this year versus security guard stuff so a lot of people in in the Fitness World in the bodybuilding world in the anti-aging world are taking growth hormone whether whether you know prescribed or otherwise um and nobody that I know has ever really done a good job

of going hey this is why they're different this is why you should look at this one rather than this one and you said you know pH is kind of a hammer and the screwdogs are more the scalpel and and that is uh definitely a thought-provoking statement I'd love to just have you kind of explain what mechanistically is happening when someone uses growth hormone that's this more broad stroke approach first yeah I think that's a little more precise yeah so growth hormone is undeniable that there are our quality of life benefits with it and in along

with that that usually is mediated via its effect directly in in certain tissues typically you know generally it's just mostly fat adipose tissue and muscle tissue so uh you know body comp's one of the major things you see but you also get a lot of other benefits reduction of carotid intermediate thickness and c-react approach chain and triglycerides and so it's having an effect on the whole system it's a very very you know broad pleiotropic product they're also abusive of growth hormone you know if you overdose it you get acromegaly symptoms you get fluid retention carpal

tunnel all these different things and and you also have sort of unproliferated or uh really an unchecked system as it turns to increasing igf-1 and so you know anyone who's been in the fitness industry has seen uh you know people with uh what they call the steroid cut right with um you know that sort of distended abdomen where these people have uh they also called columboism right after uh Palumbo the bodybuilder but uh they uh they see they have they have six facts but uh their six packs are are distended and so you and the

real reason for that is because you're proliferating on igf-1 receptors in the intestines which cause this this organ uh growth and obviously you can overdo it and so what we really can do with the peptide products is we hit it at a higher level so uh we mimic these hypothalamic hormones like real hormone releasing hormone and we are able to sort of just give the pituitary a little bit of stimulus to release these products you know one of the biggest things that happens as we age you know even around 25 our ability to secrete growth

hormone drops precipitously and so usually that's because uh not our production of somatic growth hormone and our somatotropes but they're released and so if we can encourage that release we can uh still get you know optimal levels of growth hormone but we don't have to worry about going too high or or these other negative side effects it's just really a maintenance dose to maintain optimal function as you were whenever you're in your earliest one is okay so you know most listeners by this point or maybe some of them will be aware of what those may

be and we said we've got the ipmoral intestinal moral and CJC uh and the list goes on and on and on um sir would you mind starting to maybe describe which ones are most common which ones are most efficacious which ones have the best data behind them yeah so they I really um in the clinical world right now due to some certain regulatory restrictions there are three different courses of therapy really there's a oral product which is a small molecule not a peptide called mk677 or ibda Morin the second one would be the combination relay

of the CJC 1295 also called or the one that most people policy to see that invite is is mod grf 129 and then that is usually paired with epipmorelin um and then lastly there's the testimoroland which is uh probably the most significant and Powerful uh and no serious sort of what are used clinically I would say the most common ones um are due to some some heavy usage in the past or things like the ghrp2 ghrp6 and some Moreland those have since been a little bit regulated out by yeah yeah and so they're less available

clinically but you might still see them a lot uh you know in the black market or the web but I would say the mk677 the combination of the CJC at Memorial are really the three they're used most often correctly foreign so as far as the ghrp2 and rp6 being removed was that because of misuse or maybe not being as efficacious as the ones that are current like how would you compare them yeah so um the g32 and ghrb6 uh you know unfortunately I can't tell you the reason they were removed it's a little bit of

uh lack of transparency as it relates to the FDA but can tell you that they are not nearly as specific as the upper moral and so there are two receptors on the pituitary which cause growth hormone release there's the growth hormone releasing hormone receptor and then there's the the ghrelin receptor which is also called the growth hormone secreted guide receptor and the gh52 ghrp-6 hypomoral and hexarillin and the mk677 all work on that that growth hormone security guard receptor which is usually endogenously a receptor for ghrelin uh the hunger hormone and so the g32 and

ghrb6 are are actually pretty powerful these are actually the problems the first products that they found disagree growth hormone cereal uh Bowers um found these things uh release growth hormone around 1996 through 1999. um and actually found that these things secreted growth from them before they even knew where they were working um and so that's why I sort of referenced earlier they are actually pretty powerful releasing growth woman and as a result people at traditionally really really like them the problem is they often come with other unwanted side effects things like uh you know significant

hunger probably anyways you use the ghr P6 can can say that it had you know a voracious appetite the other things though they're less notable they're less noticeable are increasing for lack increasing cortisol increasing acetylcholine so it's just not as specific as we want it to be uh the HIPAA moralin on the other hand is that first specific growth hormone secret ago and really it's a reason why she's most clinically now is because uh it definitely has an effect without The Unborn side effects so one of the protocols that I hear most often prescribed is

different in the morning and testimonial and at night then maybe alluding to the fact that those things work uh synergistically or differently is that the reality and if we could talk about that yeah definitely there's a great uh study by Anderson which shows the ability to secrete growth hormone uh whenever you do ghrp ghrp 2 G sharp six um and then you combine that I with some oral and what you see is a five to ten times um increase of growth hormone whenever you use the combination product and so what you see is that it's

actually the growth hormone secreted dogs are permissive to the effects of the growth hormone releasing hormones and so that's almost always why people will pair something like the CJC and the Upper Moreland is to get that maximum benefit I know a lot of people like the upper moral and intestinal moraling combination but you know it's probably often a little bit Overkill I think the testimony is just so uh secretory by itself that the effects that you get are pretty significant um and usually I would say it's a cost efficacy benefit with adding the epiduralin you

might see some additional benefit but uh probably not enough uh to really justify the cost now there's obviously a great deal of concern sometimes expressed around the growth hormone igf pathway with respect to cancers uh could you speak to that a little bit yeah and you know it's hard to speak on because uh you know a lot of data doesn't exist you know one of the best places to look for data is um in the children who have had post radiation therapy and treated with growth hormone as a result of Childhood Cancer and so a

lot of those uh those large-scale studies actually so reduced incidence of cancer with growth hormone therapy as a child so that's obviously positive but there's also really tight correlation between igf-1 levels um and certain types of cancer in particular uh you know prostate colon and breast and so um you know anytime we're thinking about a growth hormone therapy or igf-1 therapy that is uh definitely something we have to consider and so it's definitely something to be on the lookout for one of the things about the secret of gods is that they also raise ideiform binding

protein three which is inverse it correlated to all those same types of cancer and so it's another reason to make may be consider the security guards over you know exogenous igf-1 and growth hormone therapy super interesting so one peptide that I'd love to speak about is you know at the peptide conference there's a lot of talk around this thymus in A1 and its benefits almost like as a master reset type of them all yeah would that sound accurate I'd love to understand how that uh works and how that makes sense yeah it's my favorite of

all the peptides um you know it it looks to have all positive effects and almost no negative effects I always say that you know it in some studies has you know less side effects than Placebo um and so it's really really low risk in 2013 it got FDA work and Drug approval for malignant melanoma hepatitis C and hepatitis B and so ultimately right away we know it's great for viral illnesses and cancer um and so uh it works by essentially stimulating the innate immune system increasing you know natural killer cells uh you know T cells

helping the immune system fight anything abnormal in the body and so it can also reduce inflammation and sort of shift the immune response from a th2 to th1 immune response which can reduce inflammation so it makes it applicable in things like autoimmune diseases it makes it applicable um you know when you have cold or sickness it also makes it applicable in helping fight um the I should say the senescent cell um secretory phenotype I'm clearing the burden of some of these senescent cells which can contribute to aging um and so it's an amazing product I

think almost everyone should be on it but uh it's risks in cancer treatment and any type of viral illness make it a sort of a no-brainer and what's a recommended dosing schedule with that as far as a mountain frequency and we say everyone should be on it like all the time or just like a sickness coming on or what do you think yeah I mean yeah you know the biggest part of it is I think everyone should be on it if there wasn't you know uh you know what didn't cost me money right that's the

one downside and so um so I you know I would say that if you definitely keeps them on hand in case you you think you're coming down with a cold or going to do anything like that it's uh it's amazing it's even trying to make vaccine uh over 35 percent more efficacious and so if you're doing it something something like that it can help mitigate some of those uh those issues but um you know I think that uh the typical dosing schedule for for generally cancers around 1.6 milligrams just as two subcutaneous injections a week

um and uh it's uh again it's no risk that's a typical protocol if you're doing something like autoimmune I think most of our practitioners won't prescribe it a little bit more frequently on a uh on a daily basis very cool so one thing we talked about just prior to the podcast was Epi Talent we talked about a little bit around the podcast but I'd like to talk about mechanistically what we think is happening and then again dosing schedules as well because it seems to be there's it's kind of thrown all over the place some people

are saying you need a milligram a day and you can do it every six months some people say every three months and I'd just love to hear kind of from the horse's mouth what uh yeah what the reality is yeah definitely so mechanistically it's mimicking a pineal gland uh uh endogenously produced peptide that's often references epithalamine you know the dosing schedule is buried substantially depending on what you're trying to do I mean uh usually we try and mimic the data the study with the best data and that tends to be that 15-year follow-up study which

looks at uh you know cardiovascular morbidity and mortality um it's your significant reduction and so that dosing schedule is typically 10 milligrams um every other day or generally a total of five injections or 50 milligrams um in that good to your follow-up study that was performed essentially uh twice yearly total of 100 milligrams a year 10 injections a year and then they only did that for three years for 15 years of benefit so that is usually the dose of scheduling most of our conditions would use due to its effect on the pineal gland and regulating

melatonin and cortisol one of the other in the Circadian rhythm of those one of the other big things that typically happens is a relatively low dosing schedule usually 200 300 micrograms daily at night in order to help uh with that circadian rhythm to make it uh so that you wake up and you sleep better um and and that is a little bit less proven chemically and in the in the the data but it's still a probably frequently used in time of the day is important to acknowledge because sometimes people just with the growth hormones created

dogs it's not always clear when to take them so I'd love to maybe start with the epitolin and is it always at night or is that just if I'm looking for a specific sleep benefits yeah you know it's um there are definitely some that were done in studies that were done in the morning um and so it's clinically I would say we see that better results for sleep at night that's just the feedback we've gotten from our patients and positions but uh you know the growth hormone security guards especially it's most typically prescribed at night

to mimic that natural growth hormone pulse um if you're really trying to I would say optimize a lot of people do it uh poor fasted cardio in the morning and uh and that's also a good strategy you actually still keep the growth from a pulse at night so you're actually getting two growth in the wrong Peak instead of one which generally might have a quicker result very cool so I think a lot of the demographic um maybe listen to my podcast does a lot or maybe in the past has experimented with testosterone replacement therapy and

it's a lot of people that seemingly now are enjoying that and there's a lot of people now that are seemingly trying to get off and wondering what they can do to kind of kick start the the natural production of uh growth hormone or sort of testosterone perpetually and you know we brought up HCG and HMG and those things are great but is there any actual like peptides that you know you know that are maybe new that haven't been on the market for a while yeah definitely um so there there are two peptides that we typically

use to uh to sort of help stimulate the pituitary or the gonadotropin releasing hormones to provide you know molecular stimulating hormone um and FSH and LH 19 hormone and so those are going to be the Delta sleep inducing peptide in the kiss Neptune um one of the other things I always like to mention is that um we also do uh you know a very Clomid which is pretty popular in guys who are trying to transition out to Celestron um it's an estrogen blocker to sort of tell the body to increase the production of lhsage um

we have what's that called spirit so it's called usually called Clomid but we actually have one of those isomers so Clomid actually has two constituents of form of being in it um and uh it's a zoo and CIS clomipane I'm sorry zoo and Informer pain and we actually use the include methane as a way to be more specific with less side effects so uh that's definitely something that people are more familiar with but uh but if anyone has an issue or has had an issue with Clomid in clomipene is probably something to consider um going

back to the work of the peptides you know HCG is actually now going to be unavailable from compounding pharmacies because compounding pharmacies are unable to compound it at March 23rd at the biologic and so what's going to happen is the price is definitely going to increase a base GGA for anyone who's experiencing it and so one of the things to consider is you know those Alternatives the dsip and acceptance definitely present some of those Alternatives we've been using it in athletes for years who want to have just a little bit more LH and therefore testosterone

increase the dsip has been shown uh particularly in lies to increase uh luteinizing hormone doesn't have a ton of data but we've seen some some really good examples clinically of power to increase LH the kiss peptid is definitely has a lot more clinical data it's been used in children to sort of help start their pituitary axis to get them into puberty uh and what it does is it works on the gonadotropin releasing hormones in in the hypothalamus so it actually uh it goes really as far up in the pathway and then by activated and skin

natural open reducing hormones uh you know it will release an additropyl increasing hormone which goes to pituitary to increase LH and FSH which then allows uh you know you need to sort of restart that production it's also been used for fertility for the same reasons they're both men and women um and so that one would probably be the one that's most applicable to those individuals who are looking to get off uh what type of results have you experienced with dsip and in what populations is it something that seems to work ubiquitously or does it tend

to be very very focused yeah so most people don't really look at LH so you know I would say the majority of our uh patients who are using the DSi are usually attending it for sleep and not as much that's right that's actually my question are you getting a I guess we should clarify that that is that is my question with respect to sleep because are you getting good clinical uh results yeah wait uh yes and no I would say that uh maybe even a majority of people are unresponsive for Sleep um and it doesn't

seem to help that much one of the things we have seen help are changing it to morning dosing uh not even dosing as as most people would think and it actually comes as a 10 to one um with glycine as well um and that's actually a combination called belteran and we've gotten better clinical results to sleep with that combination but again it's it's relatively hit or miss you know I would say yeah a lot of people will see nothing and a lot of people will have you know really good sleep this is one of those

things we actually have relatively good data on because a lot of markets back to the population uses sleep trackers like worry Rings um and so uh again it's hit or miss you either have a result or you don't um but uh those people who I would say 40 45 uh they might get some effect on sleep especially if they use the Delta Rand and in the morning very cool I like to switch gears a little bit to the mitochondrial peptides you brought up there so the mutts and the human inner two ones that are very

very um interesting to me yeah very I'd just love to hear your thoughts on what the clinical data looks like yeah so uh we don't do human and um so it's one of those that we don't have any clinical experience with I've obviously read a lot of the clinical literature and it looks great um but uh you know knowing what your variant to do uh and which one to use clinically is a little bit difficult uh the hng is is really the variance of human and I would say that has the most clinical promise we

just haven't started it yet one of the the mitochondrial peptides we do at the moment are the motsc and the ss-31 that's a very exciting one as well and then we do a small molecule which also can sort of help our mitochondrial functioning uh which is called the five Amino 1mq um and so starting with the motsc that is one that's uh been relatively new to us clinically um but has some really interesting data as it relates to uh increasing mitochondrial biogenesis um and also it's interplay with longevity you know usually people start the narrative

around motsc with the narrative that the Japanese Centurion population actually expresses this at a higher levels it's polymorphism and as a result you know a lot of people think the reason they're living past 100 and so uh there's definitely some longevity benefits associated with but but also just the increasing mitochondrial biogenesis is good for energy levels it's good for a metabolic Health which is one of the big reasons people use it is that something that's seen across the board like most people are getting the mitochondrial biogenesis yeah definitely what it does is it increases de

novo purine synthesis which increases a car which increases the amp kinase which increases mitochondrial biogenesis so you're going through that sort of pathway um and a lot of people uh experience good results particularly before any type of um you know physical activity as a dosing it beforehand I will say though that uh you know clinically it's a little bit of a question mark as to the dose and dosing protocol and uh and it can slightly be a little bit irritated into uh to the skin upon injection just because of how you have to formulate it

for stability but there are developments being made to make a version that's a small molecule um that can be taken by mouth and I would say that that will probably be available within the next couple years when people hear mitochondrial biogenesis I'm going to presume everyone's ears perk up and go Hey fat loss right does that sound like yeah so then going down the path of fat loss I know you guys have a number of things that have been shown to have pretty interesting data around accelerating fat loss you know with the growth hormones secreted

dogs aside uncovered Maybe maybe there's one that we missed the 3176 love to discuss that and then anything else that comes up in the fat loss space yeah so the fat loss space is is I would say a typical one just because there's so many different mechanism mechanisms you can use to address uh energy expenditure right particularly in the fat you know I the the one products I would say that are the two most popular products for us specifically for fat loss are going to be a product called tesl sensing um tester Benzene is actually

not a peptide it's a small molecule drug but it's an ordrawal and serotonin and dopamine reuptake inhibitor and it's one of the best weight loss drugs ever studied originally studied for Parkinson's and Alzheimer's for some of those neurochemical effects of what they found is that all the patients started losing a ton of weight they actually had to stop it in the investigation of Parkinson's Alzheimer's um and instead they sort of moved over to a fat loss drug and the average weight loss over six months tends to be around 26 pounds wow I mean that's with

only uh you know the 10 with the only change is the court restrictions around 300 calories a day you know it's always difficult to judge how well the patients are doing that but when our results we've seen just phenomenal results usually it's mechanized action is generally at suppression um but it also has sort of a little bit of a thermogenic benefit as well and so that one is very very popular for us as we talk about you know specifically fat loss another one that's been really popular especially for people who are relatively optimized already um

this is what we call our fat loss cream you know and I think that's probably a misnomer it's really more body sculpting cream it's a combination of aminophiline and glyceratinic acid which is a an extract from licorice root I mean what we're able to do with that is up regulate hormone sensitive light base we're able to upregulate Camp to make sure that if your body starts to go through and burn these fat cells for energy then we can burn them in certain locations first by reducing the lipolytic threshold and we've had great results with that

you know in the some of the clinical trials they showed 11 centimeters just within Monopoly not even liquidic acid they showed 11 centimeters of uh fat loss around the waist in 12 weeks so you get a couple inches of uh yeah whilst we just one of the ingredients um and so that's a good big popular press as well and again it works better with people who are already relatively optimized because you're able to shred that bad a little bit quicker and see a difference a little bit faster man fascinating stuff so one thing that's come

into mind that I don't know if you guys are still in that space But sr909 as far as being mitochondria upregulator yeah definitely it's a it's an interesting product and and we don't have any uh experience with that here clinically uh but I do know uh because you're coming from Kentucky I've seen it used in horses quite a bit with phenomenal results um and so uh yeah in terms of uh in endurance uh and you know how long these forces can spread for it's been uh you know definitely exciting but we haven't used it at

all in human medicine okay interesting um I thought you had I thought there had been a little bit of um human data how about something like cartering is that some of you guys are experimenting with or is that outside of the realm as well yeah so the card Arena or the GW uh zero five one five one six um is uh ppri Delta Agonist which um we have stayed away from typically in human medicine just because uh some of the initial cancer research and that initial cancer research might have been overblown I think that most

people would agree that it is just because the dose was over 200 times what uh the human equal blood dose would be um and uh but still it's kept it you know it kept uh the initial manufacturers away from develop bigger more and it kept us from using it clinically I will say again that it's used a lot in the horse racing industry and the second variance as well the GW I think uh 0642 is uh it's sort of that second generation PPR Delta Agonist which also has a lot of effects you're really the only

product we have that works on those levels is a product called tetradecel thiocetic acid and uh it's more of a PPR Alpha bin Delta Agonist but we see some additional fat loss benefits for that one as well and without the negative potential cancer side effect absolutely it's uh the tetrade acid is a supplement it's able to be done even over the counter so we combine it with another product called them welexonox which has been shown it's FDA approved drug for ulcers but it's also been shown to help with type 2 diabetes and metabolic sensitivities and

so we usually combine those for some of our pre-diabetic patients with relatively good results it only bamlex oxide works at 50 of patients like the dsip it's a little bit hit and miss but uh again we still give good results of a lot of patients very cool so to the ones that I think maybe are most commonly known I'd love to touch on are are bpc 157 and we'll start there and and I think the audience may know that it's it's applicable orally or injectably it'll just maybe kind of talk about what you see with

those yeah so the bpc157 uh you know looks almost too good to be true one of the things I always like to tell people if they they looks for it they won't find any human clinical research published but it does exist up to basically clinical trials for ulcerative colitis that product has you know repair recovery effects all over the body through a variety of mechanisms of action um but uh you know our results with it from a healing standpoint have been absolutely phenomenal I don't know that there's anybody who has injury uh that's not benefited

um I have a good time span or pain or or whatever it might be for the product typically if you're using it for repair recovery we always suggest the subcutaneous injections and uh usually I would say most of our positions and they're prescribing it for more than GI related events leaky gut ulcer colitis or Crohn's they'll do the oral yeah very cool so now is that something that you suggest let's say you know pro athlete or someone who traded really hard could use on a consistent basis almost daily to accelerate recovery yeah there doesn't look

to be any I would say issues with consistent long-term dosing you know in the studies I didn't find any toxic dose so it doesn't look like it would be a problem doing it on a consistent level but again you know you'd want to see some of those published humid trials before you would say that with certainty um and uh yeah it's uh it is something I should say that it's not currently banned um by in specificity by these professional athletes or anyone who's tested there is a there is a mechanism to test it in both

blood and urine which came out in late 2017. um and it is uh technically uh you know a lot of the awesome bands things in my classes so for instance they've been anything that would be considered a fiberglass growth factor and we do know that bpc can activate fibroblasts you know it might be banned by class but I don't know right now anybody who's testing for it very very interesting and dosage-wise if you know I think a lot of people and you may agree with this is many people if not most have some GI disturbances

so dosage as far as oral Administration isn't something they should just consult with their physician or is it something you could recommend Based on data yeah so I again I would recommend that they definitely consolidate their position but with that being said I would say most of our prescribing positions will go around 500 micrograms morally uh one important thing to note about that is that uh the salt form of the pet that does matter usually all peptides are complex to Salt form um usually you know even like most just commercial products are are done that

way too for instance like sedinabil citrate but uh the the VPC actually has much much better bioavailability when it's the Arginine salt and not the acetate salt and I always want to make that clear because it definitely affects efficacy and allows you to go with that 500 microgram dose better effects very very cool so moving along to you know one one that I'm most interested in for myself is brain optimization and we talked about a few of these uh you know kind of pre-pre-podcasting as we've begun I'd love to just like which one is most

exciting to you uh right now to help it's difficult to say I would say it's either the FGL or the diet set both of those products are relatively new but also seem to be very very powerful um they have a I would say a degree of effects that is previously on scene with a lot of these therapy and you know when people like eyes are abandoning their Research into Alzheimer's and some of these neurogenic diseases these have definitely shown out um and so I would say those are by far the most exciting so mechanistically what

are we looking at there with the fgo yeah so the FGL mimics uh neural Spell adhesion molecule and so neural adhesion molecules are glycoproteins which are found on the outside of all of your your neurological cells um and uh and by activating these you can essentially spur these neuronal cells for uh outgrowth or neuride outgrowth and development um and so the FGL has been studied particularly the biggest areas are memory and Alzheimer's because what it can do is it can increase in the right outgrowth and increase it in a way that sort of creates mushroom

outgrowth which is great for long-term memory um can also make sure that cells survive so it's also been studied and that's the reason it's been studying Alzheimer's it's an interesting mechanism and it's an interesting product with a lot of diverse application applications but the thing I like about it most is it it's not just good in people who are having neurodegenerative diseases you know it's great for that you know we know it's we know it's used to treat Alzheimer's it's got great phase one and and starting that phase two clinical trials for Alzheimer's but the

other thing we know is that it's good for just everyone um for increased mental functioning and memory this is one that I probably have one of the most positive experiences with personally um in terms of you know memory I don't say that I would necessarily have a memory problem but when I take it I definitely feel sharper and remembering a little bit more obscure things I think that it definitely has an effect and and most people would be able to tell it effect sir are most people able to access this like what would I go

to my doctor and tell him if so yeah so you definitely your doctor would uh as far as I know there's not a lot of people producing it if your doctor needs any information I would always refer them to us because we definitely have a lot of that clinical information all the clinical studies and some data within our community as well and so we'd always be happy to communicate that but uh but it's relatively not well known product it got over 60 million dollars uh in Grants funding in 2016 just because of how promising it

was so you'll definitely see a lot of development and education about here in the future but it's still relatively new okay so if I go to my doctor and I say hey I just want my brain to get better get in touch with with TaylorMade like so there's not really there's not really a prescription model yet well so yeah these are definitely done by prescription on a patient-specific basis um but you know right now it's just about the knowledge it's about the education to the position um there are a lot of places that are doing

education on these topics um a lot of a lot of different educational physician groups but right now it's still like I said lesser known and so that while it's growing uh you might sort of have to take a little step to educate your own position very cool and this as far as the die hexa goes mechanistically is it similar or completely different uh completely different um what it does is it uh it was developed based off the ability of angiotensin for to have specific neurological effects um angiotensive for caused you know survival of cells it

caused uh neurotropic uh you know outgrowth so you have neuron surviving proliferating growing um it it uh one of the you know the statistics that always sort of Wows people is it has around 10 million times the potency of bdns or brain-driving trouble factor which is a strategy a lot of different people used to treat some of these conditions that they'll try and increase media now um so with its potency uh and it is sort of out of this world but what it's doing is it's mimicking uh anti-sympt4 or hepatocyte growth factor um and activating

cmet which is a receptor which has a lot of Downstream consequences to just increase uh neurogenesis um and Dr Harding from the University of Washington has been sort of in charge of this from researching angiotens and for uh throughout his career and even he who says it's been just to sort of help with most models of cognitive dysfunction they've been able to stimulate stimulate the lab I always uh if anyone is on uh you know wanting to learn more about this product I always recommend a video that you did if you search on Vimeo Joseph

Harding um and you'll you'll see a video he just did which has an awesome link of showing what the mice who were had essentially Alzheimer or Parkinson's uh induced Parkinson's through a chemical model and then treated with dihexa they do what they call a hanging rat test which they just essentially put the rat on a rope like it's doing a pull-up and then they see how long he can hang on and then they did essentially three mice one was the normal mice with no intervention the second mites was Parkinson's uh mice with no treatment and

the third mouse was uh I should say rat um was at Parkinson's treated rat a rat was treated with that hexa and what we saw is that the the rapping was actually treated with dioxide who had had that damage of Parkinson's was able to hold on twice over twice as long as the normal rat which is just you know whenever you see something like that it's just absolutely phenomenal I mean you can see sort of the power that it has to help some of these neurogenic visas and so uh the Tower of that one um

and the application across different diseases uh makes it one that's very exciting as well is that topical uh yeah so that's uh it's an interesting question it was designed by Dr Harding to be an oral available product so you know a lot of these peptides aren't stable through the GI this one it is um so we know it's an effective Worley however in our honestly you know Dr Harding after we've used this clinically as a transdermal we've actually seen really good results and so you know the the Pharma connect data has not been done as

a transdermal but we have seen clinical results um and the speculation is we actually see better clinical results as a transdermal because uh they able to bypass that hepatic metabolism it's another one that uh you know I would say that can even reduce the doses that's transdermal versus you know relatively high and extensive doses done as a worldly orally available what makes you decide whether something's going to be topical or injectable so I we didn't ask about the afternoon I'd be very curious to hear if the FGL is injectable or topical it's uh the FGL

is injectable at the moment but actually in its phase one clinical trials they did it as a nasal product the biggest issue with that is that the nasal dose is 200 micrograms and honestly would be over you know a thousand dollars per dose and so it's almost impossible to do at those levels so as a result we converted to a subcutaneous dose usually why what what allows us to sort of test these and know how to compound it is prior literature we almost do nothing here ourselves that hasn't been vetted by you know a third

party uh who's done the development in these products um occasionally we will try you know other mechanisms of action for instance the dioxin a transdermal because we know it's relatively small um and and theoretically permeable so we do often try uh occasionally uh based on the theoretic literature of how large the molecule is how hydrophobic or hydrophilic it is um you know what kinds of carriers we can use to cross the barrier um and so uh but we always do I would say subsequent testing on that um whether it be blood levels or whatever or

clinical results in terms of uh you know any other subsequent blood levels um and so uh for instance you know doing any of the growth hormones critical if there's a sublingual or you know transdermal has or an oral hasn't really ever worked and that's how we know because it doesn't increase curriculus igf one so um so those are we do a lot of due diligence so I'm making that too right and as far as cerebral I said we'll have to talk about that and it seems like very interesting I'd love to hear what the data

looks like and and what the applications are maybe mechanisms as well yeah so the this is one that has uh purified from 14 brand matter so it is uh just a collection of nerve growth factors and small peptide uh it's not just one product it's a collection of a lot of different products and so mechanism of action it's difficult to speculate on um you know uh but what we do know is that the clinical results are undeniable um particularly there's a a ton of evidence as it relates to TBI and stroke um within the windows

of three and six months um so yeah anyone is considering the survives and I would definitely consider it in those areas but beyond that it has data and uh neuropathy it has data and multiple sclerosis Parkinson's um you know Alzheimer's and so it's application and the amount of literature on this is overwhelming um however you know it's uh right now it's not an FDA group product in the U.S grouped in over 70 countries now but uh not here and then that is uh unfortunate it's going to become a lot less available in the United States

on March 23rd for the same reason that HCG will but uh but the data on this one is is absolutely phenomenal um for a variety of uh neurogenic conditions conditions or nerve conditions it's definitely one that a lot of our practitioners use the typical dosing in most of the clinical trials it's it's difficult to replicate in in you know outside of a hospital setting they were doing large uh milliliter IB infusion over the course of really 14 days that's difficult to replicate so most of our Isa positions are now prescribing as a daily subcutaneous injection

very cool is there anything else in the area of brain optimization that comes to mind that we haven't talked about yeah there's a couple you know the two I would say that are are also very very common for us are the C link and the C-Max right um both yeah both of those are Russian peptides which are nasally bioavailable actually better nasolated and subcutaneous um and uh they the see like mimics uh an immune molecule called tuxin um and uh has been shown to have antiviral capabilities as well as significant anxiolytic capabilities so uh for

anyone who's anxious that might be something to considered the C-Max is more of the one that's used for no tropical uh function for that learning and memory benefit um and that's mimicking uh aact and was designed to be a mimica based th which was uh stable on the plot and so uh those are both sprays for you know relatively short uh you know I would say durations of action uh usually between two to four hours um but you could you know learning the memory benefits you know the C-Max has been studying ADHD uh in the

series but they both have a lot of data a lot of clinical data in a variety of functions and a variety of mechanism actions so if you were in an ideal world and you had access to a doctor who's willing to prescribe this stuff and you want to optimize your brain what would you recommend as a stack like to just make the most of your brain maybe on an ongoing basis yeah so I think that the FDL definitely just from personal experience has been um uh something that I really enjoy uh the Sea Lake and

the C-Max I would say are very easy cheap and so I think the combination of those two is a great combination uh for someone like me who's an apoe three four and you know cognizant of reducing their risk of Alzheimer's I think the cerebral Palatine was also a great addition I'll do two courses a year as a preventative measure for uh for that genetic abnormality as it's been studied with 844 variants very interesting so no dioxin there uh you know the Dai hexa is uh yeah I would say at the moment is uh just questionable

for anything outside of these really serious neurogeneral diseases yeah I don't think it would necessarily be a bad thing but uh I also don't know how effective it is on a day-to-day basis to increase mental functioning uh you know we hadn't really treated a lot of those patients um and so it's a little bit difficult for me to speculate I actually know you guys don't dive into the realm of sarms anymore right since the FDA has made those changes or are those still available uh we do one sarm we do the lgd4033 due to its

amount of clinical data and uh and so we do we do well I would say quite a bit of that um and uh and generally it's very very popular um one thing you know in the realm of brain optimization is the pinelion that I hear thrown around from time to time I don't hear too much data in that space um any uh feedback or any any insight it's one that we don't do um and one of the reasons we don't do it is because we uh most of the Clone I would say the studies on

it don't have precise you know outcomes um it's just generally hey do this for optimal function but we don't have anything to measure and so um we relatively stay in a way about what uh it's really the only cabinets and peptide we typically do is that Talent very interesting um what are you most excited about in this space right now there's got to be so many new developments almost on a day-to-day basis and you guys are you doing the research and the manipulation of the molecules to try to optimize and drive studying studies definitely we've

uh worked um to do over four irbs you know in terms of uh Gathering some of that clinical data we we have an EMR platform where we try and collect uh de-identified data on some of these interventions as well um so we definitely are interested in making this so you know a sustainable long-term uh you know type of medicine and and uh you know the thing that excites me most right now is just the focus on uh preventative medicine as it relates to almost so the overlapping with the anti-aging I think that word gets a

a very very uh you know bad connotation but um as we look at things like senescence um and sirtuin activation and telomere length all of these things are great preventative medicine techniques um and uh there's now an objective measurement that's coming out called uh you know the the phenotypic age testing which looks at methylation markers under your DNA as a as a measure of your risk for death and disease and so one of the biggest things I would like to say is if you reduce your incidence of Aging by seven years you essentially cut the

spending and the incidence of disease in half all over the world and so um you know these focuses on Intervention tied to a very specific and objective marker which is just math um it's a really really exciting thing because we can really change how Healthcare is is uh looked at in the United States and make it way more preventative rather than reactionary where they come in and get a pill to treat the condition that they have but are left uh you know untreated for the preventative thing for the next time are there any peptides that

we haven't mentioned that you think the audience may be interested in and worth mentioning um yeah you know I think uh you know I think we've definitely covered a lot of the ones that really excite me I I do want to just go back to some of the the mitochondrial products the ss31 is one that's really really exciting it it goes into the inner mitochondrial membrane of the mitochondria to stabilize it and so what happens is it maximizes ATP production it reduces apoptosis in certain types of disease uh it also helps in aging help restore

muscle mass um it uh it helps with you know a variety of diseases like Alzheimer's it helps with um you know metabolic deficiencies it helps reduce you know uh the foam cell accumulation in your ELO system it's an amazing product with diverse applications which uh I think you're going to hear a lot more about in the coming years is there any human data in that or is it mostly animal data it's got phase two human data um generally the the applications are just so diverse it's going to be interesting to see what they approve for

but a lot of mouse studies a lot of dog studies and then also uh some a good amount of human data as well so something's going through this phase one phase two phase three uh FDA approval processes how does that fit into your your business model like just do things have to have FDA approval for you guys to sell them or you just sell them I don't exactly understand how that works yeah it doesn't um but the the way that we do it is it has to be a patient-specific uh prescription um from a physician

so we're still able to compound it even though it doesn't have FDA approval um but uh there are definitely some regulatory steps you have to take before that um and so those things are uh you know obviously it's something that we look at before we decide to do a product is the the body of clinical evidence so when something becomes phase one phase two approved how does that change a physician's ability to prescribe it it doesn't necessarily change the position's ability to prescribe it but it changes uh ability for us to produce it got it

very cool um so one thing we haven't talked about that I'd love to finish on is um there's never a lot of mention of potential negative implications of peptides and I think for a good reason but I'd love for you to kind of take us into that realm of you know what what are some negatives that could exist and uh what should people watch out for and there's one other question I'll follow that up with yeah so um you know the side effects are usually very very low with most of these products as I mentioned

before they don't have a lot of uh hepatic or kidney metabolism which means you don't have to worry about you know as much drug drug interaction uh you know their half-lives are relatively short so you know if there is some type of negative effect it's usually very very short lasting on the skill of minutes um um and so generally there aren't a lot of side effects the one that is sort of ubiquitous across all the peptides it's a risk for um allergic reaction or antibody response right because of the similarity to a lot of the

body's natural molecules a lot of times the immune system might pick up on these being foreign objects and then Mountain immune response um and and that is rare but definitely uh still I would say something that is a disadvantage for the molecule as a whole and a lot of times this doesn't even affect clinical function I mentioned the testamental a lot over 60 of people will experience uh you know antibody responses to the test Moreland but it doesn't affect clinical advocacy and so so it you know really depends on the product and but you know

those types of reactions are usually less than .005 percent very cool yeah I could be using the incorrect term but LPS is something that comes up a lot in um in this space that's just to do with the kind of the Purity if I'm not mistaken is like when you go to a company like yourself you're going to get um you know what I would presume to be the highest level gradient of of product and then there's kind of these sub levels and I think people need to be aware of this when you buy something

off the internet it isn't going to be at the same level and I think I just for love for you to kind of quantify that and let people understand what's actually happening and why they are different if they are yeah I've done my very very dip in so LPS or lipop polysaccharides are a byproduct of um a method of production that it's called recombinant production so they essentially will Express use the bacterias uh they'll insert a gene into bacteria that will Express the protein and then they express that that bacteria to grow and proliferate so

that it produces just a lot of this protein and then at that point they'll purify the protein um or peptide um the problem with that though is that you also have some of these lipopolysaccharides as some contaminants which can cause some really disastrous things from a health benefit um we don't do that we don't do any recommet since this all these are chemically synthesized which makes them a lot easier to control what ingredients are what you see behind me is uh preparative hplc and then the peptide synthesizer so you can see sort of what we

do in-house we have our hplc Mass Spec a little bit over there and so what we're able to do is to purify these things above 99 percentile making sure they don't don't have any product which looks you know very very similar which you might have a negative reaction um and so with all of these things there's just a high level of control you know we are FDA regulated we have the FDA in here often we have uh regulations by over 47 different Pharmacy boards um and so we're definitely heavily regulated to make sure that we're

giving the best product and that we're giving a product sterile endotoxin-free um and all of those things are important when you consider using it in yourself is that the only um difference in consideration of people buying things and again I don't want to say black market necessarily because I know these aren't necessarily uh negative drugs when it comes to the FDA they're just kind of unregulated a lot of them so when someone buys something off the internet and I won't throw a site out there but how does that stand against quality that what you guys

are doing yeah so most of those products are produced in China and have essentially no regulatory control um you know uh we have tested a lot of those products um and you know I wouldn't expect anyone to believe our data but I would Point them to a New York Times article uh it's called sort of the vast heart of a doping conspiracy by Michael Powell um and in it they reference it 80 of those products not online or fraudulent or take um which uh you know obviously the majority and and beyond that you just don't

know what you're getting I think uh and it's not the only consideration you know endotoxin like I said sterility or obviously big consideration um Purity and potency are big consideration um identity of the product of big considerations uh and and honestly there are some there have been some legal prosecutions for those things as well in terms of distribution so uh overall it is it is not something I would ever recommend and everyone thinks I think they have a great source but uh you can never be uh sure um and so in hplc Mass Effect at

it is not no that's the other thing I would say um it is uh it is definitely not enough you're not you don't know for instance with hplc mass spec you dissolve it in a solvent which allows you not to gauge what type of salt it is in the process of doing these chemically a lot of times you have to use a really strong acid called trifluoroacetic acid to uh in the process and a lot of times uh people who manufacture these things in order to save money we'll leave it there but the TFA salt

can be really liver toxic and can cause some negative side effects within the body so again hplc Mass Spec is not enough so you really need something that's regulated and it has third party testing and so obviously I don't even have to talk about sterility which can be uh you know one of the most important things right Ryan does Taylor May distribute just in America or is it North American and Europe as well or where you guys are licensed yeah so uh tell me in the U.S only uh distributes to I think 47 different states

right now but we also have a facility in the Middle East as well as in this facility uh in Australia and so those typically been are the areas of distribution but that's always changing um then we're uh continue to add different areas of the world good for you man you know what I think you've answered all the questions I'm sure there's about a thousand more I could throw out you but I know your time is precious and and I'm so grateful where if there's doctors out there that want to reach out to TaylorMade and get

in contact get educated maybe what's the best uh course of action for them yeah so I always recommend them to to just look us up online and call us to that number where they can even email me directly uh at RS taylormadecompiling.com I will say uh for pretty patients out there uh legally I'm not allowed to I have a lot of patient direct patient interaction um and so I usually just suggest that they find a position they can work with or we often do referrals as well um but I am a little bit limited to

those patients who might reach out to me very cool Ryan thank you so much for your time incredibly grateful and uh keep doing what you do man I'm definitely a fan of following what you're doing yeah thanks so much for having me appreciate it [Music] and that is a rap ladies and gentlemen I told you that guys absolutely brilliant not a hesitation not a pause his understanding and expertise in the area of peptides is tremendous now I've experimented with quite a few peptides as I may or may not have mentioned in this podcast um these

things are incredible now sourcing is a completely different thing please go through your doctor try to find a doctor who has an open mind maybe a Doctor Who's a little more advanced in their knowledge base they do exist um there's many of them around the country in the U.S Canada and certainly Europe uh even the Middle East I know that are certainly experienced and dabbling in the Realms of peptides it seems these peptides offer tremendous benefit and as long as you understand what you're doing so there's some great resources that you may want to start

exploring Vladimir cavinson is the guy I mentioned the podcast who's the Godfather of peptides he's um believe's website is cavinson.info and uh it's so much research on that on that site to give you guys a little more insights and I'm not going to recommend any particular peptides or peptide sources but um definitely explore with your doc and uh my always suggestion is if you are going to experiment with these things do not get them off random internet sites that you're not familiar with because there's a lot of implications as Ryan did mention these things are

not tightly regulated yet by the FDA so pay attention take care of your body take care of yourself have an amazing day and don't forget to breathe to walk and ideally spend at least 10 to 15 minutes each morning meditating to create your mind because an amazing life awaits you on the other side of that chatter that exists in your mind I promise have an amazing day guys love it cheers [Music] tuning into muscle intelligence [Music] start with at least one person you know make sure you're subscribed so you never miss an episode this podcast

is for information purposes only statements and views on this podcast are not medical advice this podcast including them because the producers disclaim responsibility for any possible adverse effects from the use of information contained here and opinions of guests are their own and this podcast does not endorse or accept responsibility for statements made by guests this podcast does not make any representations or warranties about Guest qualifications or credibility this podcast may contain paid endorsements or advertisements for products or Services individuals on this podcast may have a direct or indirect financial interest and products or Services referred

to here in if you think you have a medical problem consult a licensed physician