The SHOCKING Side Effects Of OZEMPIC... | Ozempic Expert Johann Hari

how many people are willing to take it because as you as we discuss this now say that there's I don't know a million 10 million people that listen what percentage of those people on average would go do you know what that sounds like the thing I've been looking for if they're Americans and the polling is Right 47% of Americans have said they would be willing to take they want to take these drugs actively want oh they want to so about 50% of this a the audience will be actively wanting to take it as we sit

here now yeah and now tell me why they shouldn't well there's a huge array of risks um some of which are very very serious so I'll give you a few examples I go through Lots in the book there's a professor in France called Professor Jean Luke F who works at the University Hospital in melier who was commissioned by the French medicines agency to investigate these drugs and the safety around these drugs and one of the reasons lots of people have felt very happy about the safety of these drugs and it's a good reason is that

in their roll out for obesity is people have said like Daniel duer for example who I mentioned to discovered gp1 they say quite rightly well look diabetics have been taking these drugs for 18 years now if there was some catastrophic effect we would know it would have emerged in diabetics right now he would also add well it could affect obese people a bit differently than diabetics so there's some gaps in the knowledge but he said look we this drug has been used by enormous numbers of people all over the world without some huge safety concern

emerging but others have said okay let's really dig into those diabetics then so that's what Professor F did so they've got they've got very good health databases in France the best in the world so he decided to look at diabetics who' taken these drugs for three years sometime between 2006 and I think 2015 so he looks at loads of the diabetics who've taken them and then he compared them to a group of other diabetics who were very similar in every other way but had not taken these drugs to see are there differences in outcome and

he was particularly looking for one outcome we know that when you give these drugs to rats they are much more likely to develop thyroid cancer so he's looking okay is there a difference in thyroid cancer risk in this population and what he discovered was very sobering it was published so the people who' taken the drugs had a 50 to 75% increase in their risk of thyroid cancer now when I first said that I was like what the [ __ ] you have to understand what that doesn't mean that doesn't mean 50 to 75% of people

who take the drug get thyroid cancer if if it was that outcome they would pull it immediately and no one would ever take again what it means is whatever your thyroid cancer risk was at the start it will go up by between 50 to 75% if this research is correct right this then is being further investigated there are some scientists who dispute it the European medic medicine's agency has not been persuaded by the evidence so far but that's pretty sobering right that's you know 1.2% of people get thyroid cancer in their lifetime 84% of them

I think survive you know a big increasing people getting thyroid cancer when you're talking about millions of people across the world taking it is is very alarming what about this thing called AEK face yeah I'm not worried about that purely purely for a selfish reason so AEK face is where um I worried about it for other people a zic face is where you lose so much weight that your face looks really gaunt and you look kind of hollow and bit my face is so naturally round like babies always smile at me I think because they

think I'm their King I'm just like a baby that inex got to walk around um I'm I could lose so much weight in my face and not look G that I'm not worried about that myself it's there's no um health problem with asmic face it's just you know the vanity thing well vanity is too negative a word it's you know people don't want to look gone and Ill that's fair enough pancreitis pancreatitis is a rare side effect but it's very very unpleasant so um pancreatitis is basically where uh your pancreas just goes Haywire as a

result of taking these drugs I interviewed a woman called Michelle AK who's in mytle beach in North Carolina so she started taking these drugs and her doctor said to her you know there's a few side effects one of them is pancreatitis and she said go no my luck I'll probably get it she starts take it was really happy with the weight loss 6 weeks later she went to Pittsburg to visit her daughter she woke up in the worst Agony she's ever been in she had this excruciating pain running all from below her breast around to

her back she was vomiting she was [ __ ] herself she was screaming being in pain and her son-in-law phoned for an ambulance he thought she was about to die she was in such a state of distress she arrives at the hospital and they um discovered something G really wrong with her pancreas they said are you a heavy drinker she said no then they said are you taking OIC and it's kind of revealing that was the second question they asked so we know that um if you take OIC there's a study by the University of

British Columbia that found it increases your risk of pancreatitis by a factor of nine so you're nine times more likely to get it's still rare you're very unlikely to get pancreatitis even when you times it by 9 it's still a very rare outcome but you know doctors often compare it to the pain of being stabbed Michelle said to me it was much worse than the pain of child birth right they had to give a fenil to take the pain away so if you get medical care you recover but so it's worth people knowing that is

a significant risk uh of just an excruciatingly painful condition one of my friends has started taking a zmek you know there's this word on the side of this um pen in front of me semaglutide semaglutide yeah what did I say it's you said it the way intive the way the scientist say I think seml it says it looks like semaglutide exactly that's how I said it until all the scientists kept correcting me in a slightly patronizing way but yeah what's the actual word semaglutide and is that the chemical and is Zex the brand yeah exactly

so semaglutide so there's there's several Brands um so there's stide which is the drug which has this glp1 Agonist effect um as zic is the one for diabetes wovi is the one for obesity they're exactly the same drug they're made in the same Factory they're identical it's just that wovi is marketed for obesity and you can in the US not here yet prescribe wovi for higher doses than you would for for for diabetics and then there's other drugs that are coming along the line so there's munaro which is made by Eli Lily so oena wovi

produces an average of 15% loss of body weight over a year mojarro causes a loss of 21 1% on average and the next one that will come down the line it's probably going to come out next year Triple G causes 24.2% the reason mjo Works differently so this only works on gp1 munaro adds another gut hormone Gip so it works on two gut hormones not just one and Triple G works on three gut hormones and there's going to be more and more drugs I mean there's 37 gut hormones that can affect appetite they think so

there's going to be lots of variants of these drugs with different side effect profiles different risks different benefits fits so yeah this is you know one of the a South African psychiatrist called Carell laru who's been at the absolute Forefront of the developments and they said to me you know when a baby starts to walk it's been crawling for ages and then it just stands up and it walks and we are at that point and it was striking how how much the scientists kept describing it as a game Cher you know one of them Tim

Spectre who I think you might have had on described as um it's like they found the Holy Grail they found the thing that causes weight loss right uh Robert Kushner said that to me who's another one of the scientists been at the heart of it said we cracked open the treasure chest we found the thing that controls weight it's your gut hormones so I worry about the parallels with previous diet drugs and we can talk about that these are new drugs working in a new way and the the overwhelming feeling in the science is no

this really is different my friend is um a biotech billionaire and um when I when I saw him not say he's at the very Forefront of all of these things he takes so many different things to optimize his life one of them he started taking is his zek and last time I saw him he was um we're in the gym together and he was significantly weaker he was significantly skinnier but I noticed when we did our exercises he was significantly weaker as well and that strikes me as a bit of an unspoken about side effect

is muscle loss it's one of the 12 big risks that I write about in the book so muscle mass loss is a real problem people who don't know muscle mass is the total amount of soft tissue that you have in your body and it's essential for doing anything that requires movement and strength basically and any form of weight loss causes a reduction in muscle mass so if you someone's bu overweight and they lose a huge amount of weight on a diet they lose a lot of muscle mass hopefully you lose more fat mass than muscle

mass but you lose a lot of muscle you can't control that right you just there's no way to lose a lot of weight that doesn't involve some muscle mass loss unless you're very very lucky right um so obviously this triggers a huge amount of muscle mass loss and there's real worries with that right um if you lose muscle mass so you naturally lose muscle mass from when you're 30 onwards anyway you lose quite a lot every year it's incredibly depressing when you look at the figures you lose muscle mass naturally every year anyway um but

if you lose too much muscle mass you won't you'll be a bit weaker now but the real risks are when you're older so if you have really low muscle mass when you're older you're at risk of a condition called sarcopenia which is Greek for poverty of the flesh basically just means you'll really struggle to climb the stairs do any kind of physical activity you're more likely to fall if you do fall you're more likely to die it's it's quite a serious thing and this I think is particularly going to be an issue for people who

are already skinny like the people at that party we were talking about right at the start none of them were fat at the start right people who were already skinny who were taking it to be super skinny they're going to see they're going to have real issues with their muscle mass likely when they're older so this is a very serious problem we could be building up a time bomb of more frail older people for further down the line you lose up to 20 to 30% of your lean muscle mass when you start taking a zet

says in your book as one of the risk Prof that's for for some people yeah actually weirdly I was 33% fat Mass when I started and I went down to 22% I think it is now so I lost nothing but fat Mass but I suspect that might be for the slightly humiliating reason that I had no muscle to start with but I'm not sure and then on the psychology the mental health side of things suicidality there's some cases where suicidality things like feelings of anxiety and depression increase is that that because of the underlying reasons

why we're eating the self- soothing stuff or is that a separate side effect so it's hely debated there isn't even agreement that the drugs cause that effect in a minority of people you got to bear in mind at any given time some of the population becomes suicidal some of them will be taking these drugs so it's very hard to disentangle that especially early on uh so some scientists would say there isn't even any evidence they cause suicidality among the scientists who fear that it may cause suicidality there's a big debate some of it will be

you're deprived of comfort food uh or pleasure some of it will be as Carell Laro put it to me a lot of people who are overweight for a long time say you know the reason my life is [ __ ] is because I'm overweight if I finally lose weight my life will be good and then they lose weight and they've still got the same [ __ ] husband and they've still got the same job they don't like and they suddenly go into this crisis where they're like oh it wasn't the weight that was blocking me

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