David Sinclair - Supplements for a Longer Life

the third one you mentioned is athletic greens because i'm on a vegetarian vegan diet i describe myself as a a newbie struggling vegan um i need nutrients and so athletic greens is full of vitamins and and plant-based whole foods that ensures that i don't lack those nutrients because if you're just eating a vegan diet and i've also given up dairy you want to make sure that there's adequate nutrition i don't want to go too deep on supplements i think you talk at length for over an hour in lifespan which is your podcast on supplements the

third episode i think i i do want to talk about three in particular that seem to keep coming up across a lot of people i know who are super focused on health you bring up animen resveratrol and athletic greens and you take those every day talk to me about those three and why you take them and what they do to your body in the context of slowing or reversing aging right so let's take them one by one resveratrol is a small what's called a polyphenol it's produced by many plants to survive it's produced by grapes

and it's concentrated in red wine it should be a white powder it shouldn't be brown if you buy it and it's brown throw it away i take a gram of it every morning with rare exceptions when i'm traveling and i forget it but i mix it with a little bit of yogurt because it just a little bit like a couple of teaspoons or today i had a bit of avocado because resveratrol is insoluble in water and often people take it and it doesn't get absorbed so do that why does it work well we we have

shown in many animal studies and people now shown in human studies that it's activating uh one of the main sertuan pathways called sir t1 and it does that like an accelerator pedal the chemical residual will bind to the enzyme and make it work faster now that's the accelerator pedal for t1 the gas or the petrol is nad nad is a molecule that we need for life without it we're dead in 30 seconds and nad um isn't something that you can um well you can swallow it but the best bang for the buck is to eat

molecules that the body uses to make this nad molecule and the one that i choose to take is called nmn short for nicotinamide mononucleotide but think of it as m ms but just flip the letters around don't eat m m's you won't live longer you can eat m ms but if you want to live longer don't do that but the nmn is important because it's the immediate precursor to make nad and the body makes nad very rapidly and i know from clinical trials that i've been involved with that taking a gram of nmn which i

do every day raises nad levels in whole blood in the cells in the blood probably in the rest of my body as well it's hard to test that without a tissue sample i'm not going to give up my brain anytime soon but the doubling of that nad is important because as we get older we make less of this chemical we have about half the levels of nad in our skin for example as i i have half the levels if i didn't supplement that i would have made when i was 20. um and so i boost

those levels back up to being youthful and then the idea is that the sort of defenses are activated um and that's enhanced by the diet that i have as well as a little bit of exercise now the third one you mentioned is athletic greens because i'm on a vegetarian vegan diet i describe myself as a a newbie struggling vegan i need nutrients and so athletic greens is full of vitamins and and plant-based whole foods that ensures that i don't lack those nutrients because if you're just eating a vegan diet and i've also given up dairy

you want to make sure that there's adequate nutrition so you know i'm i'm on one meal a day basically oh mad but i want to add another couple of letters which is a n omad a n i just made that up by the way shane so trademarked that madden let's call it adequate nutrition put that on the end and that's what athletic greens does for me um [Music] i do take one other drug called metformin which is a type 2 diabetes drug that has been shown to associate with longer life and less diseases in old

age by looking at type 2 diabetics and there's a stunning stunning fact that type 2 diabetics that would normally have a short life span when they take metformin typically at two grams a day i'm on one gram a day by the way they actually have less diseases and live longer than people that don't have type 2 diabetes you